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» Authors » Vasudevan Sudarsanam

Vasudevan Sudarsanam

Explore the profile of Vasudevan Sudarsanam including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 18
Citations 112
Followers 0
Related Specialties
Chemistry
Biochemistry
Neurology
Top 10 Co-Authors
Kamala K Vasu
Harish Padh
Manish Nivsarkar
Parendu D Rathod
Ajay D Pillai
Navedul Haque
Franklin P Xavier
Khurshid I Molvi
Hitesh Vaidya
Rajesh D Das
Published In
Bioorg Med Chem
Eur J Med Chem
J Enzyme Inhib Med Chem
Biochem Biophys Res Commun
Phytother Res
Affiliations
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Recent Articles
1.
Investigations on substituted (2-aminothiazol-5-yl)(imidazo[1,2-a]pyridin-3-yl)methanones for the treatment of Alzheimer's disease
Sagar S, Singh D, Das R, Panchal N, Sudarsanam V, Nivsarkar M, et al.
Bioorg Med Chem . 2021 Mar; 36:116091. PMID: 33676335
Alzheimer's disease (AD) is a neurodegenerative disease majorly affecting old age populations. Various factors that affect the progression of the disease include, amyloid plaque formation, neurofibrillary tangles, inflammation, oxidative stress,...
2.
Pharmacological investigation of quinoxaline-bisthiazoles as multitarget-directed ligands for the treatment of Alzheimer's disease
Sagar S, Singh D, Das R, Panchal N, Sudarsanam V, Nivsarkar M, et al.
Bioorg Chem . 2019 Jun; 89:102992. PMID: 31174042
Alzheimer's disease (AD) is the most prevalent disease of old age leading to dementia. Complex AD pathogenesis involves multiple factors viz. amyloid plaque formation, neurofibrillary tangles and inflammation. Herein we...
3.
Thiazolyl-thiadiazines as Beta Site Amyloid Precursor Protein Cleaving Enzyme-1 (BACE-1) Inhibitors and Anti-inflammatory Agents: Multitarget-Directed Ligands for the Efficient Management of Alzheimer's Disease
Sagar S, Singh D, Panchal N, Das R, Pandya D, Sudarsanam V, et al.
ACS Chem Neurosci . 2018 Apr; 9(7):1663-1679. PMID: 29697965
Alzheimer's disease (AD) is associated with multiple neuropathological events including β-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibition and neuronal inflammation, ensuing degeneracy, and death to neuronal cells. Targeting such...
4.
Stability-indicating assay method for determination of actarit, its process related impurities and degradation products: Insight into stability profile and degradation pathways
Abiramasundari A, Joshi R, Jalani H, Sharma J, Pandya D, Pandya A, et al.
J Pharm Anal . 2018 Feb; 4(6):374-383. PMID: 29403903
The stability of the drug actarit was studied under different stress conditions like hydrolysis (acid, alkaline and neutral), oxidation, photolysis and thermal degradation as recommended by International Conference on Harmonization...
5.
New insight into adenosine receptors selectivity derived from a novel series of [5-substituted-4-phenyl-1,3-thiazol-2-yl] benzamides and furamides
Inamdar G, Pandya A, Thakar H, Sudarsanam V, Kachler S, Sabbadin D, et al.
Eur J Med Chem . 2013 May; 63:924-34. PMID: 23685887
A series of [5-substituted-4-phenyl-1,3-thiazol-2-yl] benzamide and furamide analogues were investigated in radioligand binding studies at adenosine receptor subtypes with an aim to obtain potent and selective adenosine receptor ligands. Benzamide...
6.
Beneficial effects of swertiamarin on dyslipidaemia in streptozotocin-induced type 2 diabetic rats
Vaidya H, Prajapati A, Rajani M, Sudarsanam V, Padh H, Goyal R
Phytother Res . 2012 Jan; 26(8):1259-61. PMID: 22228612
Dyslipidaemia is one of the major risk factors for cardiovascular disease in diabetes mellitus. Lipid changes associated with diabetes mellitus are attributed to increases in free fatty acid flux, secondary...
7.
Synthesis and evaluation of quinazolinone derivatives as inhibitors of NF-kappaB, AP-1 mediated transcription and eIF-4E mediated translational activation: inhibitors of multi-pathways involve in cancer
Giri R, Thaker H, Giordano T, Chen B, Nuthalapaty S, Vasu K, et al.
Eur J Med Chem . 2010 Jun; 45(9):3558-63. PMID: 20557982
In our effort to discover and develop small molecule multi-pathway inhibitors which may be useful as tools for treating cancerous conditions, we have synthesized a small library of 2-thiazole-5-yl-3H-quinazolin-4-one derivatives....
8.
Design, synthesis and evaluation of novel 2-thiophen-5-yl-3H-quinazolin-4-one analogues as inhibitors of transcription factors NF-kappaB and AP-1 mediated transcriptional activation: Their possible utilization as anti-inflammatory and anti-cancer...
Giri R, Thaker H, Giordano T, Williams J, Rogers D, Vasu K, et al.
Bioorg Med Chem . 2010 Mar; 18(7):2796-808. PMID: 20335039
In an attempt to discover novel inhibitors of NF-kappaB and AP-1 mediated transcriptional activation utilizing the concept of chemical lead based medicinal chemistry and bioisosterism a series of 2-(2,3-disubstituted-thiophen-5-yl)-3H-quinazolin-4-one analogs...
9.
2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists
Scheiff A, Yerande S, El-Tayeb A, Li W, Inamdar G, Vasu K, et al.
Bioorg Med Chem . 2010 Mar; 18(6):2195-2203. PMID: 20188574
A series of 2-amino-5-benzoyl-4-phenylthiazole derivatives was investigated in radioligand binding studies at adenosine receptor (AdoR) subtypes with the goal to obtain potent and A(1)-selective antagonists. Acylation of the 2-amino group...
10.
Antihyperlipidaemic activity of swertiamarin, a secoiridoid glycoside in poloxamer-407-induced hyperlipidaemic rats
Vaidya H, Rajani M, Sudarsanam V, Padh H, Goyal R
J Nat Med . 2009 Jul; 63(4):437-42. PMID: 19633811
We have investigated antihyperlipidaemic effect of swertiamarin (50 mg/kg, oral once) isolated from the perennial herb Enicostemma littorale Blume in poloxamer 407 (P-407)-induced hyperlipidaemic rats. Rats were made hyperlipidaemic by...