Antihyperlipidaemic Activity of Swertiamarin, a Secoiridoid Glycoside in Poloxamer-407-induced Hyperlipidaemic Rats

Overview

Journal J Nat Med

Publisher Springer

Date 2009 Jul 28

PMID 19633811

Citations 14

Authors

Hitesh Vaidya

Mandapati Rajani

Vasudevan Sudarsanam

Harish Padh

Ramesh Goyal

Affiliations

Soon will be listed here.

Abstract

We have investigated antihyperlipidaemic effect of swertiamarin (50 mg/kg, oral once) isolated from the perennial herb Enicostemma littorale Blume in poloxamer 407 (P-407)-induced hyperlipidaemic rats. Rats were made hyperlipidaemic by intraperitoneal administration of P-407 (400 mg/kg). Serum lipid levels such as total cholesterol, triglycerides and low-density lipoprotein cholesterol increased significantly (P < 0.001) compared with normal control rats. All these changes were significantly prevented in the rats treated with swertiamarin. Serum high-density lipoprotein (HDL) cholesterol was found to be reduced in the P-407 control rats. However, administration of swertiamarin significantly (P < 0.01) increased HDL levels and it showed a significant lipid-lowering effect, as well as a high antiatherogenic potential. Overall swertiamarin is an effective lipid-lowering lead compound and can be useful for preventing atherosclerosis.

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