Valmik D Dhakane
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Explore the profile of Valmik D Dhakane including associated specialties, affiliations and a list of published articles.
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9
Citations
75
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Recent Articles
1.
Thakare V, Lakade S, Mahajan M, Kulkarni Y, Dhakane V, Harde M, et al.
Eur J Pharmacol
. 2021 Mar;
898:173992.
PMID: 33675783
Amelioration of oxidative stress via promoting the endogenous antioxidant system and enhancement of monoamines in brain were the important underlying antidepressant mechanism of protocatechuic acid (PCA). The aim of the...
2.
Thakare V, Patil R, Suralkar A, Dhakane V, Patel B
Metab Brain Dis
. 2019 Mar;
34(3):775-787.
PMID: 30848471
The main objective of the present study is to investigate potential effects of PCA in OBX induced depressive-like behavior in rat model. PCA was administered at a dose of 100 ...
3.
Thakare V, Patil R, Oswal R, Dhakane V, Aswar M, Patel B
J Psychopharmacol
. 2017 Dec;
32(2):223-235.
PMID: 29215318
Silymarin, a plant-derived polyphenolic flavonoid of Silybum marianum, elicited significant antidepressant-like activity in an acute restraint stress model of depression. It improved monoamines, mainly 5-hydroxytryptamine (5-HT) levels in the cortex,...
4.
Thakare V, Dhakane V, Patel B
Metab Brain Dis
. 2016 Oct;
32(2):401-413.
PMID: 27785705
Protocatechuic acid ethyl ester (PCA), a phenolic compound, exhibits neuroprotective effects through improving endogenous antioxidant enzymatic and nonezymatic system. Based on the role of oxidative stress in modulating depressive disorders...
5.
Thakare V, Dhakane V, Patel B
Pharmacol Rep
. 2016 Jul;
68(5):1020-7.
PMID: 27428764
Background: Silymarin is a polyphenolic flavanoid of Silybum marianum, elicited neuroprotection and antidepressant like activity in stressed model. It was found to increase 5-hydroxytryptamine (5-HT) levels in the cortex and...
6.
Dhakane V, Thakare V, Dongare S, Bhale P, Mule Y, Bandgar B, et al.
Chem Biol Drug Des
. 2015 Dec;
87(6):878-84.
PMID: 26715009
This study investigates anti-inflammatory activity with improved pharmacokinetic and non-ulcerogenic properties of various novel synthesized prodrugs of ketoprofen in experimental animals. Prodrugs 3a, 3f and 3k were found to possess...
7.
Chavan H, Adsul L, Kotmale A, Dhakane V, Thakare V, Bandgar B
J Enzyme Inhib Med Chem
. 2014 Mar;
30(1):22-31.
PMID: 24666306
Abstract A series of novel pyrazole-based chalcones have been designed, synthesized from 1-methyl-5-(2,4,6-trimethoxyphenyl)-1H-pyrazole (6). The structures of regioisomers 6 and 7 were determined by 2D (1)H-(1)H COSY, (1)H-(13)C HSQC and...
8.
Chavan H, Bandgar B, Adsul L, Dhakane V, Bhale P, Thakare V, et al.
Bioorg Med Chem Lett
. 2013 Jan;
23(5):1315-21.
PMID: 23357629
A series of novel pyrazole amalgamated flavones has been designed and synthesized from 1-methyl-5-(2,4,6-trimethoxy-phenyl)-1H-pyrazole 6. The structures of regioisomers 6 and 7 were resolved by 2D (1)H-(1)H COSY, (1)H-(13)C HSQC...
9.
Adsul L, Bandgar B, Chavan H, Jalde S, Dhakane V, Shirfule A
J Enzyme Inhib Med Chem
. 2012 Dec;
28(6):1316-23.
PMID: 23230954
A novel series of carbazole substituted aminopyrimidines (5a-p) were synthesized and screened for their in vitro urease inhibition and antimicrobial activity. Among the compounds, 4-(2,4-dichlorophenyl)-6-(9-methyl-9H-carbazol-3-yl)-pyrimidin-2-amine (5i) was found to be...