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Metabolic Brain Disease

Metabolic Brain Disease is a peer-reviewed journal that focuses on the study of disorders affecting the brain's metabolism. It publishes research articles, reviews, and case reports exploring the underlying mechanisms, diagnosis, and treatment of various metabolic brain diseases, including inherited metabolic disorders, neurodegenerative diseases, and mitochondrial dysfunction. The journal serves as a valuable resource for researchers, clinicians, and healthcare professionals interested in advancing our understanding and management of these complex conditions.
Details
Abbr. Metab Brain Dis
Publisher Springer
Start 1986
End Continuing
Frequency Quarterly
p-ISSN 0885-7490
e-ISSN 1573-7365
Country United States
Language English
Specialties Neurology
Endocrinology
Metrics
h-index / Ranks: 4506 78
SJR / Ranks: 4991 831
CiteScore / Ranks: 4133 5.70
JIF / Ranks: 2654 3.6
Recent Articles
1.
Protective effects of omega-3 against procarbazine-induced brain damage in the cerebellum and CA1 Hippocampus of male rats: a focus on oxidative stress mechanisms
Abolghasemi M, Shamsara A, Nozari M, Eftekhar-Vaghefi R, Baghalishahi M, Roodbari A, et al.
Metab Brain Dis . 2025 Mar; 40(3):153. PMID: 40088343
The study examined the combined effects of procarbazine (PCZ) and omega-3 on cognitive functions, motor skills, and brain histology in male rats over ten days. While PCZ has antitumor properties,...
2.
Metabolic pathways and genes involved in treatable and non-treatable metabolic epilepsies. A comprehensive review and metabolic pathway analysis
Sesse A, Ladias P, Kostoulas C, Chatzistefanidis D, Georgiou I, Markoula S
Metab Brain Dis . 2025 Mar; 40(3):152. PMID: 40085371
More than 600 different metabolic disorders can lead to a clinical picture, where seizures are a main neurological manifestation, either as the primary clinical finding or as a part of...
3.
Effects of a mitochondrial calcium uniporter and P-selectin inhibitors on neural injury induced by global cerebral ischemia-reperfusion in male rats
Javanmardi S, Moradpour F, Veisi M, Omidian N, Kavyannejad R
Metab Brain Dis . 2025 Mar; 40(3):150. PMID: 40085331
Neural injury following ischemia-reperfusion (I/R) is induced by multiple pathophysiological pathways. This study aimed to use mitochondrial calcium channel and p-selectin inhibitors to weaken these pathways. One hundred and two...
4.
Effects of quercetin and derivatives on NAMPT/Sirtuin-1 metabolic pathway in neuronal cells: an approach to mitigate chemotherapy-induced cognitive impairment
John J, Das S, Kunnath A, Mudgal J, Nandakumar K
Metab Brain Dis . 2025 Mar; 40(3):151. PMID: 40085284
 The cognitive alterations observed in individuals undergoing cancer treatments have garnered more attention recently. Chemotherapy can reduce nicotinamide adenine dinucleotide (NAD+) levels by inhibiting nicotinamide phosphoribosyl transferase (NAMPT). This reduction...
5.
Quercetin inhibited chronic unpredictable mild stress-induced mouse depressive behaviors through attenuating lateral Habenula neuronal activities
Cai Y, Chen D, Li K, Dong J, Li C, Liu Y, et al.
Metab Brain Dis . 2025 Mar; 40(3):149. PMID: 40085279
As a flavonoid, quercetin has shown anti-tumor, anti-inflammation, and anti-depressant effects. However, the exact anti-depressant mechanism of quercetin remains unclear. In this study, a combination of behavioral tests and neuropharmacological...
6.
JNK inhibition mitigates sepsis-associated encephalopathy via attenuation of neuroinflammation, oxidative stress and apoptosis
Gagnani R, Singh H, Suri M, Bali A
Metab Brain Dis . 2025 Mar; 40(3):148. PMID: 40080264
Sepsis-associated encephalopathy (SAE) is a severe complication of sepsis, leading to cognitive dysfunction and neuronal damage. C-Jun N-terminal kinases (JNKs), a subset of the MAP kinase family, have attracted substantial...
7.
Suppression of miR-218 promotes SOCS3 expression to alleviate cognitive impairment and white matter injury after chronic cerebral hypoperfusion
Zhu Y, Tong J, Jiang J, Shi K, Xie J, Zhu Y, et al.
Metab Brain Dis . 2025 Mar; 40(3):147. PMID: 40080253
Chronic cerebral hypoperfusion-induced white matter injury (WMI) is a significant cause of vascular cognitive impairment. Emerging evidence suggests that miR-218 may be involved in the pathogenesis of WMI. However, understanding...
8.
Gamma-aminobutyric acid and glutamate system dysregulation in a small population of Egyptian children with autism spectrum disorder
Meguid N, Ismail S, Anwar M, Hashish A, Semenova Y, Abdalla E, et al.
Metab Brain Dis . 2025 Mar; 40(3):146. PMID: 40080228
Autism spectrum disorder (ASD) is associated with various symptoms, including repetitive behaviors, restricted interests, and deficits in proper communication. Earlier studies have linked these symptoms to abnormalities in the balance...
9.
Tetrapleura tetraptera fruit extracts ameliorate pentylenetetrazol-induced seizures as well as ensuing cognitive deficit and oxidative stress
Ekong M, Bassey O, Pessu N, Kpobari G, Okuku E, Bassey R, et al.
Metab Brain Dis . 2025 Mar; 40(3):143. PMID: 40072755
Kindling is an experimental-induced seizure consistent with epilepsy disease, a chronic neurological disorder characterised by spontaneous and repeated seizures. This disease is associated with oxidative stress, and most therapeutic strategies...
10.
Investigating cuproptosis and mitochondrial dysfunction in brain cells: uncovering novel mechanisms and biomarkers for Parkinson's disease
Li Q, Li D, Li Y, Yang K, Ren Y
Metab Brain Dis . 2025 Mar; 40(3):144. PMID: 40072691
Parkinson's disease (PD) is a chronic neurodegenerative condition marked by the gradual degeneration of dopaminergic neurons, resulting in a range of disabling motor and non-motor symptoms. Despite advances, the molecular...