Uwe Sauer
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Explore the profile of Uwe Sauer including associated specialties, affiliations and a list of published articles.
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234
Citations
12831
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Recent Articles
1.
Gruber C, Noor E, Buffing M, Sauer U
Proc Natl Acad Sci U S A
. 2025 Mar;
122(10):e2423767122.
PMID: 40048276
Recent physical binding screens suggest that protein-metabolite interactions are more extensive than previously recognized. To elucidate the functional relevance of these interactions, we developed a mass spectrometry-based screening method for...
2.
Pontrelli S, Sauer U
Biol Methods Protoc
. 2025 Mar;
10(1):bpaf014.
PMID: 40046731
Polysaccharide quantification plays a vital role in understanding ecological and nutritional processes in microbes, plants, and animals. Traditional methods typically hydrolyze these large molecules into monomers using chemical methods, but...
3.
Schubert C, Nguyen B, Sichert A, Napflin N, Sintsova A, Feer L, et al.
Nat Commun
. 2025 Feb;
16(1):1735.
PMID: 39966379
The carbohydrates that fuel gut colonization by S. Typhimurium are not fully known. To investigate this, we designed a quality-controlled mutant pool to probe the metabolic capabilities of this enteric...
4.
Golan O, Gampp O, Eckert L, Sauer U
NPJ Syst Biol Appl
. 2025 Feb;
11(1):17.
PMID: 39929850
Microorganisms primarily utilize nutrients to generate biomass and replicate. When a single nutrient source is available, the produced biomass typically increases linearly with the initial amount of that nutrient. This...
5.
Seisenbacher G, Nakic Z, Borras E, Sabido E, Sauer U, de Nadal E, et al.
Cell Rep
. 2025 Jan;
44(2):115224.
PMID: 39847483
The redox state of proteins is essential for their function and guarantees cell fitness. Peroxiredoxins protect cells against oxidative stress, maintain redox homeostasis, act as chaperones, and transmit hydrogen peroxide...
6.
Nguyen B, Sintsova A, Schubert C, Sichert A, Scheidegger C, Naf J, et al.
Cell Host Microbe
. 2024 Sep;
32(10):1758-1773.e4.
PMID: 39293436
How enteric pathogens adapt their metabolism to a dynamic gut environment is not yet fully understood. To investigate how Salmonella enterica Typhimurium (S.Tm) colonizes the gut, we conducted an in ...
7.
Sollier J, Basler M, Broz P, Dittrich P, Drescher K, Egli A, et al.
Nat Microbiol
. 2024 Jan;
9(1):1-3.
PMID: 38177300
No abstract available.
8.
Holbrook-Smith D, Trouillon J, Sauer U
Annu Rev Biophys
. 2023 Dec;
53(1):41-64.
PMID: 38109374
Over the past decades, our understanding of microbial metabolism has increased dramatically. Metabolomics, a family of techniques that are used to measure the quantities of small molecules in biological samples,...
9.
Clerc E, Raina J, Keegstra J, Landry Z, Pontrelli S, Alcolombri U, et al.
Nat Commun
. 2023 Dec;
14(1):8080.
PMID: 38057294
The ability of marine bacteria to direct their movement in response to chemical gradients influences inter-species interactions, nutrient turnover, and ecosystem productivity. While many bacteria are chemotactic towards small metabolites,...
10.
Trouillon J, Doubleday P, Sauer U
Cell Syst
. 2023 Oct;
14(10):860-871.e4.
PMID: 37820729
Our knowledge of transcriptional responses to changes in nutrient availability comes primarily from few well-studied transcription factors (TFs), often lacking an unbiased genome-wide perspective. Leveraging recent advances allowing bacterial genomic...