Hannes Link
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Explore the profile of Hannes Link including associated specialties, affiliations and a list of published articles.
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61
Citations
1262
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Recent Articles
1.
Lubrano P, Smollich F, Schramm T, Lorenz E, Alvarado A, Eigenmann S, et al.
Mol Syst Biol
. 2025 Jan;
21(3):274-293.
PMID: 39748127
Metabolic variation across pathogenic bacterial strains can impact their susceptibility to antibiotics and promote the evolution of antimicrobial resistance (AMR). However, little is known about how metabolic mutations influence metabolism...
2.
Doello S, Sauerwein J, von Manteuffel N, Burkhardt M, Neumann N, Appel J, et al.
Curr Biol
. 2024 Dec;
35(1):77-86.e4.
PMID: 39626669
Transitioning into and out of dormancy is a crucial survival strategy for many organisms. In unicellular cyanobacteria, surviving nitrogen-starved conditions involves tuning down their metabolism and reactivating it once nitrogen...
3.
Pahl V, Lubrano P, Trossmann F, Petras D, Link H
Cell Rep Methods
. 2024 Nov;
4(12):100908.
PMID: 39603242
Detecting strain-specific barcodes with mass spectrometry can facilitate the screening of genetically engineered bacterial libraries. Here, we introduce intact protein barcoding, a method to measure protein-based library barcodes and metabolites...
4.
Pakkir Shah A, Walter A, Ottosson F, Russo F, Navarro-Diaz M, Boldt J, et al.
Nat Protoc
. 2024 Sep;
20(1):92-162.
PMID: 39304763
Feature-based molecular networking (FBMN) is a popular analysis approach for liquid chromatography-tandem mass spectrometry-based non-targeted metabolomics data. While processing liquid chromatography-tandem mass spectrometry data through FBMN is fairly streamlined, downstream...
5.
Warneke R, Herzberg C, Weiss M, Schramm T, Hertel D, Link H, et al.
J Bacteriol
. 2024 Jun;
206(7):e0019024.
PMID: 38832794
Cyclic di-adenosine monophosphate (c-di-AMP) is a second messenger involved in diverse metabolic processes including osmolyte uptake, cell wall homeostasis, as well as antibiotic and heat resistance. This study investigates the...
6.
Maier L, Stein-Thoeringer C, Ley R, Brotz-Oesterhelt H, Link H, Ziemert N, et al.
Lancet Microbe
. 2024 Apr;
5(8):100843.
PMID: 38608681
The incidence of antibiotic-resistant bacterial infections is increasing, and development of new antibiotics has been deprioritised by the pharmaceutical industry. Interdisciplinary research approaches, based on the ecological principles of bacterial...
7.
Mardoukhi M, Rapp J, Irisarri I, Gunka K, Link H, Marienhagen J, et al.
Microb Biotechnol
. 2024 Mar;
17(3):e14429.
PMID: 38483038
Glutamate serves as the major cellular amino group donor. In Bacillus subtilis, glutamate is synthesized by the combined action of the glutamine synthetase and the glutamate synthase (GOGAT). The glutamate...
8.
Ben Nissan R, Milshtein E, Pahl V, de Pins B, Jona G, Levi D, et al.
Elife
. 2024 Feb;
12.
PMID: 38381041
Synthetic autotrophy is a promising avenue to sustainable bioproduction from CO. Here, we use iterative laboratory evolution to generate several distinct autotrophic strains. Utilising this genetic diversity, we identify that...
9.
Presti L, Link H
Cell Rep Methods
. 2024 Jan;
4(1):100697.
PMID: 38262347
In this issue of Cell Reports Methods, Rachwalski et al. describe a high-throughput method to screen genetic interactions in bacteria using a conjugative CRISPR interference (CRISPRi) plasmid. The method enables...
10.
Schramm T, Lubrano P, Pahl V, Stadelmann A, Verhulsdonk A, Link H
Mol Syst Biol
. 2023 Aug;
19(10):e11596.
PMID: 37642940
Temperature-sensitive (TS) mutants are a unique tool to perturb and engineer cellular systems. Here, we constructed a CRISPR library with 15,120 Escherichia coli mutants, each with a single amino acid...