Ugo Chiacchio
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Explore the profile of Ugo Chiacchio including associated specialties, affiliations and a list of published articles.
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31
Citations
156
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Recent Articles
1.
Campisi A, Raciti G, Sposito G, Grasso R, Chiacchio M, Spatuzza M, et al.
Int J Mol Sci
. 2021 Apr;
22(7).
PMID: 33806203
Herein, we assessed the effect of full native peptide of amyloid-beta (Aβ) (1-42) and its fragments (25-35 and 35-25) on tissue transglutaminase (TG2) and its isoforms (TG2-Long and TG2-Short) expression...
2.
Chiacchio M, Lanza G, Chiacchio U, Giofre S, Romeo R, Iannazzo D, et al.
Curr Med Chem
. 2018 Dec;
26(41):7337-7371.
PMID: 30501590
Heterocyclic compounds represent a significant target for anti-cancer research and drug discovery, due to their structural and chemical diversity. Oxazoles, with oxygen and nitrogen atoms present in the core structure,...
3.
Zagni C, Pistara V, Oliveira L, Castilho R, Romeo G, Chiacchio U, et al.
Eur J Med Chem
. 2017 Oct;
141:188-196.
PMID: 29031066
Histone deacetylase inhibitors (HDACis) play an important role as valuable drugs targeted to cancer therapy: several HDACis are currently being tested in clinical trials. Two new potential HDACis 1a and...
4.
Floresta G, Talotta C, Gaeta C, De Rosa M, Chiacchio U, Neri P, et al.
J Org Chem
. 2017 Apr;
82(9):4631-4639.
PMID: 28406307
A green and efficient 1,3-dipolar cycloaddition of nitrones with different styrenes and cinnamates using a catalytic amount of γ-cyclodextrin (γ-CD) in water has been developed to give substituted isoxazolidines. γ-CD...
5.
Romeo R, Carnovale C, Giofre S, Chiacchio M, Garozzo A, Amata E, et al.
Beilstein J Org Chem
. 2015 Mar;
11:328-34.
PMID: 25815087
A novel series of 2'-oxa-3'-aza-4'a-carbanucleosides, featured with a triazole linker at the 5'-position, has been developed by exploiting a click chemistry reaction of 5'-azido-2'-oxa-3'-aza-4'a-carbanucleosides with substituted alkynes. Biological tests indicate...
6.
Lombardo G, Rescifina A, Chiacchio U, Bacchi A, Punzo F
Acta Crystallogr B Struct Sci Cryst Eng Mater
. 2014 Jan;
70(Pt 1):172-80.
PMID: 24441140
The crystal structure of racemic dimethyl (4RS,5RS)-3-(4-nitrophenyl)-4,5-dihydroisoxazole-4,5-dicarboxylate, C13H12N2O7, has been determined by single-crystal X-ray diffraction. By analysing the degree of growth of the morphologically important crystal faces, a ranking of...
7.
Chiacchio U, Barbera V, Bonfanti R, Broggini G, Campisi A, Gazzola S, et al.
Bioorg Med Chem
. 2013 Aug;
21(18):5748-53.
PMID: 23916151
A series of 1,7,8,8a-tetrahydro-3H-oxazolo[3,4-a]pyrazin-6(5H)-ones has been synthesized by an intramolecular, palladium(II) catalyzed, aminooxygenation of alkenyl ureas, readily available from glycine allylamides as starting materials. Biological tests showed that the obtained...
8.
Cordaro M, Risitano F, Scala A, Rescifina A, Chiacchio U, Grassi G
J Org Chem
. 2013 Mar;
78(8):3972-9.
PMID: 23506161
A new method for the preparation of highly functionalized β-enamino diones has been developed. The protocol involves an initial self-catalyzed Mannich-type reaction of enolizable cyclic 1,3-dicarbonyls to nitrones, followed by...
9.
Lombardo G, Portalone G, Chiacchio U, Rescifina A, Punzo F
Dalton Trans
. 2012 Oct;
41(47):14337-44.
PMID: 23044598
The vast literature concerning caffeic acid and its derivatives lacks any reference to the solid state structures of its inorganic salts as these crystals are quite difficult grow. Most of...
10.
Romeo R, Carnovale C, Giofre S, Romeo G, Macchi B, Frezza C, et al.
Bioorg Med Chem
. 2012 May;
20(11):3652-7.
PMID: 22549138
Truncated phosphonated C-1'-branched N,O-nucleosides have been synthesized in good yields by 1,3-dipolar cycloaddition methodology, starting from N-methyl-C-(diethoxyphosphoryl)nitrone 7. Preliminary biological assays show that β-anomers are able to inhibit HIV in...