Tony Kouzarides
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Explore the profile of Tony Kouzarides including associated specialties, affiliations and a list of published articles.
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113
Citations
24211
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Recent Articles
1.
Klimontova M, Zhang H, Campos-Laborie F, Webster N, Andrews B, Kim Chung K, et al.
PLoS One
. 2024 Dec;
19(12):e0314655.
PMID: 39656728
RNA-modifying enzymes have recently garnered considerable attention due to their relevance in cancer biology, identifying them as potential targets for novel therapeutic intervention. THUMPD3 was recently identified as an RNA...
2.
Klimontova M, Kim Chung K, Zhang H, Kouzarides T, Bannister A, Hili R
ACS Chem Biol
. 2024 Nov;
19(12):2399-2405.
PMID: 39611406
In recent years, RNA-modifying enzymes have gained significant attention due to their impact on critical RNA-based processes and, consequently, human pathology. However, identifying sites of modifications throughout the transcriptome remains...
3.
Herridge R, Dolata J, Migliori V, de Santis Alves C, Borges F, Schorn A, et al.
Nat Struct Mol Biol
. 2024 Sep;
32(2):277-286.
PMID: 39242979
Developmental epigenetic modifications in plants and animals are mostly reset during gamete formation but some are inherited from the germline. Small RNAs guide these epigenetic modifications but how inherited small...
4.
Herridge R, Dolata J, Migliori V, de Santis Alves C, Borges F, Schorn A, et al.
bioRxiv
. 2023 Jul;
PMID: 37398006
Epigenetic modifications that arise during plant and animal development, such as DNA and histone modification, are mostly reset during gamete formation, but some are inherited from the germline including those...
5.
Tsagkogeorga G, Santos-Rosa H, Alendar A, Leggate D, Rausch O, Kouzarides T, et al.
Commun Biol
. 2022 Aug;
5(1):868.
PMID: 36008532
RNA methylation plays an important role in functional regulation of RNAs, and has thus attracted an increasing interest in biology and drug discovery. Here, we collected and collated transcriptomic, proteomic,...
6.
Ruivo C, Bastos N, Adem B, Batista I, Duraes C, Melo C, et al.
Gut
. 2022 Jan;
PMID: 35012996
Objective: Intratumor heterogeneity drives cancer progression and therapy resistance. However, it has yet to be determined whether and how subpopulations of cancer cells interact and how this interaction affects the...
7.
Leger A, Amaral P, Pandolfini L, Capitanchik C, Capraro F, Miano V, et al.
Nat Commun
. 2021 Dec;
12(1):7198.
PMID: 34893601
RNA molecules undergo a vast array of chemical post-transcriptional modifications (PTMs) that can affect their structure and interaction properties. In recent years, a growing number of PTMs have been successfully...
8.
Han N, Hwang W, Tzelepis K, Schmerer P, Yankova E, MacMahon M, et al.
Sci Adv
. 2021 Jul;
7(27).
PMID: 34193418
The global outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) necessitates the rapid development of new therapies against coronavirus disease 2019 (COVID-19) infection. Here, we present the identification of...
9.
Burgess H, Depledge D, Thompson L, Srinivas K, Grande R, Vink E, et al.
Genes Dev
. 2021 Jun;
35(13-14):1005-1019.
PMID: 34168039
N-methyladenosine (mA) is an abundant internal RNA modification, influencing transcript fate and function in uninfected and virus-infected cells. Installation of mA by the nuclear RNA methyltransferase METTL3 occurs cotranscriptionally; however,...
10.
Santos-Rosa H, Millan-Zambrano G, Han N, Leonardi T, Klimontova M, Nasiscionyte S, et al.
Mol Cell
. 2021 May;
81(13):2793-2807.e8.
PMID: 33979575
DNA replication initiates at genomic locations known as origins of replication, which, in S. cerevisiae, share a common DNA consensus motif. Despite being virtually nucleosome-free, origins of replication are greatly...