Tom N Grammatopoulos
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Explore the profile of Tom N Grammatopoulos including associated specialties, affiliations and a list of published articles.
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21
Citations
552
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Recent Articles
1.
Fortin M, LaCroix A, Grammatopoulos T, Tan L, Wang Q, Manca D
Sci Rep
. 2023 Nov;
13(1):21054.
PMID: 38030645
Liposomal formulations are hypothesized to alleviate anthracycline cardiotoxicity, although this has only been documented clinically for doxorubicin. We developed an in vitro multiparametric model using human-induced pluripotent stem cell-derived cardiomyocytes...
2.
van Kraaij S, Pereira D, Smal B, Summo L, Konkel A, Lossie J, et al.
Clin Transl Sci
. 2023 May;
16(7):1258-1271.
PMID: 37177864
The development of pharmacological therapies for mitochondrial diseases is hampered by the lack of tissue-level and circulating biomarkers reflecting effects of compounds on endothelial and mitochondrial function. This phase 0...
3.
Cuddy L, Alia A, Salvo M, Chandra S, Grammatopoulos T, Justman C, et al.
Mol Neurodegener
. 2022 Aug;
17(1):54.
PMID: 35987691
Background: Amyloid plaque deposition and axonal degeneration are early events in AD pathogenesis. Aβ disrupts microtubules in presynaptic dystrophic neurites, resulting in the accumulation of impaired endolysosomal and autophagic organelles...
4.
Banerjee D, Grammatopoulos T, Palmisciano A, Klinger J, Krishnan I, Whittenhall M, et al.
Chest
. 2020 Mar;
158(2):735-738.
PMID: 32112775
No abstract available.
5.
Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein
Cuddy L, Wani W, Morella M, Pitcairn C, Tsutsumi K, Fredriksen K, et al.
Neuron
. 2019 Oct;
104(5):869-884.e11.
PMID: 31648898
Age-related neurodegenerative disorders are characterized by a slow, persistent accumulation of aggregated proteins. Although cells can elicit physiological responses to enhance cellular clearance and counteract accumulation, it is unclear how...
6.
Nicholas D, Proctor E, Raval F, Ip B, Habib C, Ritou E, et al.
PLoS One
. 2017 Feb;
12(2):e0170975.
PMID: 28178278
Numerous studies show that mitochondrial energy generation determines the effectiveness of immune responses. Furthermore, changes in mitochondrial function may regulate lymphocyte function in inflammatory diseases like type 2 diabetes. Analysis...
7.
Woodhead J, Brock W, Roth S, Shoaf S, Brouwer K, Church R, et al.
Toxicol Sci
. 2016 Sep;
155(1):61-74.
PMID: 27655350
Tolvaptan is a selective vasopressin V2 receptor antagonist, approved in several countries for the treatment of hyponatremia and autosomal dominant polycystic kidney disease (ADPKD). No liver injury has been observed...
8.
Grammatopoulos T, Jones S, Yoshimura M, Hoover B, Das M, Snyder E, et al.
Stem Cell Res Ther
. 2010 Dec;
1(5):36.
PMID: 21122109
Introduction: Regulated neurotransmitter actions in the mammalian central nervous system determine brain function and control peripheral organs and behavior. Although drug-seeking behaviors, including alcohol consumption, depend on central neurotransmission, modification...
9.
Liu Z, Meray R, Grammatopoulos T, Fredenburg R, Cookson M, Liu Y, et al.
Proc Natl Acad Sci U S A
. 2009 Mar;
106(12):4635-40.
PMID: 19261853
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is linked to Parkinson's disease (PD) and memory and is selectively expressed in neurons at high levels. Its expression pattern suggests a function distinct from that...
10.
Ahmadi F, Grammatopoulos T, Poczobutt A, Jones S, Snell L, Das M, et al.
Neurochem Res
. 2007 Nov;
33(5):886-901.
PMID: 17992568
Among various types of neurons affected in Parkinson's disease, dopamine (DA) neurons of the substantia nigra undergo the most pronounced degeneration. Products of DA oxidation and consequent cellular damage have...