Alternative Splicing of the Cardiac Sodium Channel in Pulmonary Arterial Hypertension

Overview

Journal Chest

Publisher Elsevier

Specialty Pulmonary Medicine

Date 2020 Mar 1

PMID 32112775

Citations 5

Authors

Debasree Banerjee

Tom N Grammatopoulos

Amy Palmisciano

James R Klinger

Ipsita Krishnan

Mary Whittenhall

Anyu Zhou

Samuel Dudley

Corey E Ventetuolo

Affiliations

Soon will be listed here.

Citing Articles

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A Heart Failure-Associated Splice Variant Leads to a Reduction in Sodium Current Through Coupled-Gating With the Wild-Type Channel.

Zheng Y, Wan X, Yang D, Ramirez-Navarro A, Liu H, Fu J Front Physiol. 2021; 12:661429.

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Right ventricular dysfunction and long-term risk of death.

Sanders J, Koestenberger M, Rosenkranz S, Maron B Cardiovasc Diagn Ther. 2020; 10(5):1646-1658.

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RNA-Binding Proteins in Pulmonary Hypertension.

Zhang H, Brown R, Stenmark K, Hu C Int J Mol Sci. 2020; 21(11).

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References

Shang L, Pfahnl A, Sanyal S, Jiao Z, Allen J, Banach K . Human heart failure is associated with abnormal C-terminal splicing variants in the cardiac sodium channel. Circ Res. 2007; 101(11):1146-54. PMC: 3157752. DOI: 10.1161/CIRCRESAHA.107.152918. View

Xu W, Koeck T, Lara A, Neumann D, DiFilippo F, Koo M . Alterations of cellular bioenergetics in pulmonary artery endothelial cells. Proc Natl Acad Sci U S A. 2007; 104(4):1342-7. PMC: 1783136. DOI: 10.1073/pnas.0605080104. View

Simonneau G, Gatzoulis M, Adatia I, Celermajer D, Denton C, Ghofrani A . Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol. 2013; 62(25 Suppl):D34-41. DOI: 10.1016/j.jacc.2013.10.029. View

Gao G, Xie A, Zhang J, Herman A, Jeong E, Gu L . Unfolded protein response regulates cardiac sodium current in systolic human heart failure. Circ Arrhythm Electrophysiol. 2013; 6(5):1018-24. PMC: 3909518. DOI: 10.1161/CIRCEP.113.000274. View

Gao G, Brahmanandam V, Raicu M, Gu L, Zhou L, Kasturirangan S . Enhanced risk profiling of implanted defibrillator shocks with circulating SCN5A mRNA splicing variants: a pilot trial. J Am Coll Cardiol. 2014; 63(21):2261-9. PMC: 4096784. DOI: 10.1016/j.jacc.2014.02.588. View

Ahmadi A, Ohira H, Mielniczuk L . FDG PET imaging for identifying pulmonary hypertension and right heart failure. Curr Cardiol Rep. 2014; 17(1):555. DOI: 10.1007/s11886-014-0555-7. View

Gao G, Xie A, Huang S, Zhou A, Zhang J, Herman A . Role of RBM25/LUC7L3 in abnormal cardiac sodium channel splicing regulation in human heart failure. Circulation. 2011; 124(10):1124-31. PMC: 3172047. DOI: 10.1161/CIRCULATIONAHA.111.044495. View

Lundgrin E, Park M, Sharp J, Tang W, Thomas J, Asosingh K . Fasting 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography to detect metabolic changes in pulmonary arterial hypertension hearts over 1 year. Ann Am Thorac Soc. 2013; 10(1):1-9. PMC: 3960991. DOI: 10.1513/AnnalsATS.201206-029OC. View

Tonelli A, Arelli V, Minai O, Newman J, Bair N, Heresi G . Causes and circumstances of death in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2013; 188(3):365-9. PMC: 3778730. DOI: 10.1164/rccm.201209-1640OC. View

10.

Zhang R, Wu Y, Zhao M, Liu C, Zhou L, Shen S . Role of HIF-1alpha in the regulation ACE and ACE2 expression in hypoxic human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2009; 297(4):L631-40. DOI: 10.1152/ajplung.90415.2008. View