David G Standaert
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Explore the profile of David G Standaert including associated specialties, affiliations and a list of published articles.
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182
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7326
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Recent Articles
1.
Middlebrooks E, Patel V, Popple R, Walker H, Thomas E, Brinkerhoff S, et al.
J Neurosurg
. 2025 Feb;
:1-10.
PMID: 39951712
Objective: Stereotactic radiosurgery (SRS) is an effective treatment for refractory tremor. However, the lack of reliable patient-specific targeting biomarkers leads to varying outcomes. Although connectomic-based targeting is commonly used in...
2.
Sampson T, Wallen Z, Won W, Standaert D, Payami H, Harms A
Sci Rep
. 2025 Feb;
15(1):4014.
PMID: 39893159
Growing evidence indicates that persons with Parkinson disease (PD), have a unique composition of indigenous gut microbes. Given the long prodromal or pre-diagnosed period, longitudinal studies of the human and...
3.
Anderson K, Marras C, Amara A, Chahine L, Eberly S, Hosamath A, et al.
Parkinsonism Relat Disord
. 2024 Nov;
130:107190.
PMID: 39579746
Objective: To understand what Parkinson's Disease (PD) patients report in their own words about their mood and anxiety problems using the Parkinson's Disease Patient Report of Problems (PD-PROP). Methods: Patient-reported...
4.
Samant R, Standaert D, Harms A
Front Cell Neurosci
. 2024 Nov;
18:1476461.
PMID: 39564189
Disease-associated microglia (DAM) are a subset of microglia that appear at various stages of central nervous system neurodegenerative diseases. DAM were identified using single-cell RNA sequencing within Alzheimer's Disease (AD)...
5.
Scarduzio M, Eskow Jaunarajs K, Standaert D
Neurobiol Dis
. 2024 Sep;
201:106685.
PMID: 39343248
Altered interaction between striatonigral dopaminergic (DA) inputs and local acetylcholine (ACh) in striatum has long been hypothesized to play a central role in the pathophysiology of dystonia and dyskinesia. Indeed,...
6.
Hong H, Wang Y, Menard M, Buckley J, Zhou L, Volpicelli-Daley L, et al.
J Neuroinflammation
. 2024 Sep;
21(1):216.
PMID: 39218899
Parkinson's disease (PD) is characterized by neuroinflammation, progressive loss of dopaminergic neurons, and accumulation of α-synuclein (α-Syn) into insoluble aggregates called Lewy pathology. The Line 61 α-Syn mouse is an...
7.
Purks J, Arbatti L, Hosamath A, Amara A, Anderson K, Chahine L, et al.
Neurol Clin Pract
. 2024 Jul;
14(5):e200334.
PMID: 38962394
Background And Objectives: Cognitive impairment is experienced by up to 80% of people with Parkinson disease (PD). Little is known regarding the subjective experience and frequency of bothersome cognitive problems...
8.
Yuan Y, Li H, Sreeram K, Malankhanova T, Boddu R, Strader S, et al.
Mol Neurodegener
. 2024 Jun;
19(1):47.
PMID: 38862989
Background: LRRK2-targeting therapeutics that inhibit LRRK2 kinase activity have advanced to clinical trials in idiopathic Parkinson's disease (iPD). LRRK2 phosphorylates Rab10 on endolysosomes in phagocytic cells to promote some types...
9.
Dean M, Standaert D
Curr Opin Neurol
. 2024 May;
37(4):409-413.
PMID: 38780079
Purpose Of Review: to review recent progress in the development and use of continuous levodopa therapies in Parkinson disease (PD). Recent Findings: Levodopa/Carbidopa intestinal gel (LCIG) is a continuous levodopa...
10.
Figge D, Amaral H, Crim J, Cowell R, Standaert D, Eskow Jaunarajs K
J Neurosci
. 2024 Apr;
44(26).
PMID: 38664012
l-DOPA-induced dyskinesia (LID) is a debilitating motor side effect arising from chronic dopamine (DA) replacement therapy with l-DOPA for the treatment of Parkinson's disease. LID is associated with supersensitivity of...