Tom Lesluyes
Overview
Explore the profile of Tom Lesluyes including associated specialties, affiliations and a list of published articles.
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Articles
45
Citations
789
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Recent Articles
1.
John E, Lesluyes T, Baker T, Tarabichi M, Gillenwater A, Wang J, et al.
Sci Rep
. 2024 Sep;
14(1):22591.
PMID: 39343812
Oral potentially malignant disorders (OPMDs) with genomic alterations have a heightened risk of evolving into oral squamous cell carcinoma (OSCC). Currently, genomic data are typically obtained through invasive tissue biopsy....
2.
Jiang Y, Montierth M, Yu K, Ji S, Guo S, Tran Q, et al.
bioRxiv
. 2024 Jul;
PMID: 39005348
Intra-tumor heterogeneity is an important driver of tumor evolution and therapy response. Advances in precision cancer treatment will require understanding of mutation clonality and subclonal architecture. Currently the slow computational...
3.
Baker T, Lai S, Lynch A, Lesluyes T, Yan H, Ogilvie H, et al.
Cancer Discov
. 2024 Jun;
14(10):1810-1822.
PMID: 38943574
Tumors frequently display high chromosomal instability and contain multiple copies of genomic regions. Here, we describe Gain Route Identification and Timing In Cancer (GRITIC), a generic method for timing genomic...
4.
Pourebrahim R, Heinz Montoya R, Akiyama H, Ostermann L, Khazaei S, Muftuoglu M, et al.
Cell Rep Med
. 2024 May;
5(5):101558.
PMID: 38733986
The investigation of the mechanisms behind p53 mutations in acute myeloid leukemia (AML) has been limited by the lack of suitable mouse models, which historically have resulted in lymphoma rather...
5.
Kuzmin E, Baker T, Lesluyes T, Monlong J, Abe K, Coelho P, et al.
Cell Rep
. 2024 Mar;
43(4):113988.
PMID: 38517886
The basal breast cancer subtype is enriched for triple-negative breast cancer (TNBC) and displays consistent large chromosomal deletions. Here, we characterize evolution and maintenance of chromosome 4p (chr4p) loss in...
6.
Fontanges Q, Dubos P, Lesluyes T, Laizet Y, Velasco V, Melendez B, et al.
Genes Chromosomes Cancer
. 2024 Mar;
63(3):e23229.
PMID: 38481055
A close relationship has been demonstrated between genomic complexity and clinical outcome in uterine smooth muscle tumors. We studied the genomic profiles by array-CGH of 28 fumarate hydratase deficient leiomyomas...
7.
Huang K, Ma H, Chong R, Uchihara T, Lian B, Zhu F, et al.
Cancer Cell
. 2023 Oct;
41(12):2019-2037.e8.
PMID: 37890493
Intestinal metaplasia (IM) is a pre-malignant condition of the gastric mucosa associated with increased gastric cancer (GC) risk. Analyzing 1,256 gastric samples (1,152 IMs) across 692 subjects from a prospective...
8.
Nurminen A, Jaatinen S, Taavitsainen S, Hognas G, Lesluyes T, Ansari-Pour N, et al.
Genome Med
. 2023 Oct;
15(1):82.
PMID: 37828555
Background: Prostate cancer (PrCa) genomic heterogeneity causes resistance to therapies such as androgen deprivation. Such heterogeneity can be deciphered in the context of evolutionary principles, but current clinical trials do...
9.
Michot A, Lagarde P, Lesluyes T, Darbo E, Neuville A, Baud J, et al.
Cancers (Basel)
. 2023 Jul;
15(13).
PMID: 37444560
Background: The management of soft-tissue sarcoma (STS) relies on a multidisciplinary approach involving specialized oncological surgery combined with other adjuvant therapies to achieve optimal local disease control. Purpose and Results:...
10.
Cross W, Lyskjaer I, Lesluyes T, Hargreaves S, Strobl A, Davies C, et al.
Genome Med
. 2022 Aug;
14(1):99.
PMID: 36042521
Background: Central conventional chondrosarcoma (CS) is the most common subtype of primary malignant bone tumour in adults. Treatment options are usually limited to surgery, and prognosis is challenging. These tumours...