Todd D Armstrong
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Explore the profile of Todd D Armstrong including associated specialties, affiliations and a list of published articles.
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40
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2477
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Recent Articles
1.
Wehrli M, Guinn S, Birocchi F, Kuo A, Sun Y, Larson R, et al.
Clin Cancer Res
. 2024 Feb;
30(9):1859-1877.
PMID: 38393682
Purpose: Targeting solid tumors with chimeric antigen receptor (CAR) T cells remains challenging due to heterogenous target antigen expression, antigen escape, and the immunosuppressive tumor microenvironment (TME). Pancreatic cancer is...
2.
Baugh A, Gonzalez E, Narumi V, Kreger J, Liu Y, Rafie C, et al.
bioRxiv
. 2024 Feb;
PMID: 38352476
Preclinical murine models in which primary tumors spontaneously metastasize to distant organs are valuable tools to study metastatic progression and novel cancer treatment combinations. Here, we characterize a novel syngeneic...
3.
Zabransky D, Chhabra Y, Fane M, Kartalia E, Leatherman J, Huser L, et al.
Cancer Res
. 2024 Feb;
84(8):1221-1236.
PMID: 38330147
Significance: Aged pancreatic fibroblasts secrete GDF-15 and activate AKT signaling to promote pancreatic cancer growth, highlighting the critical role of aging-mediated changes in the pancreatic cancer microenvironment in driving tumor...
4.
Huff A, Longway G, Mitchell J, Andaloori L, Davis-Marcisak E, Chen F, et al.
JCI Insight
. 2023 Dec;
8(23).
PMID: 38063199
Personalized cancer vaccines aim to activate and expand cytotoxic antitumor CD8+ T cells to recognize and kill tumor cells. However, the role of CD4+ T cell activation in the clinical...
5.
Delitto D, Zabransky D, Chen F, Thompson E, Zimmerman J, Armstrong T, et al.
Oncoimmunology
. 2021 Nov;
10(1):2001159.
PMID: 34777919
Tumor involvement of major vascular structures limits surgical options in pancreatic adenocarcinoma (PDAC), which in turn limits opportunities for cure. Despite advances in locoregional approaches, there is currently no role...
6.
Ho W, Croessmann S, Lin J, Phyo Z, Charmsaz S, Danilova L, et al.
J Clin Invest
. 2021 Jul;
PMID: 34283806
Both epidemiologic and cellular studies in the context of autoimmune diseases have established that protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a key regulator of T cell receptor (TCR)...
7.
Ho W, Erbe R, Danilova L, Phyo Z, Bigelow E, Stein-OBrien G, et al.
Genome Biol
. 2021 May;
22(1):154.
PMID: 33985562
Background: The majority of pancreatic ductal adenocarcinomas (PDAC) are diagnosed at the metastatic stage, and standard therapies have limited activity with a dismal 5-year survival rate of only 8%. The...
8.
Lopez-Bujanda Z, Chaimowitz M, Armstrong T, Foote J, Emens L, Drake C
Oncoimmunology
. 2021 Jan;
9(1):1809926.
PMID: 33457094
Significance: Prostate cancer is a leading cause of cancer-related death in men worldwide, with an estimated 33,000 deaths projected in the U.S. in 2020. Although primary (localized) tumors can be...
9.
Zaidi N, Soban M, Chen F, Kinkead H, Mathew J, Yarchoan M, et al.
JCI Insight
. 2020 Sep;
5(17).
PMID: 32879142
In prior studies, we delineated the landscape of neoantigens arising from nonsynonymous point mutations in a murine pancreatic cancer model, Panc02. We developed a peptide vaccine by targeting neoantigens predicted...
10.
Yarchoan M, Ho W, Mohan A, Shah Y, Vithayathil T, Leatherman J, et al.
JCI Insight
. 2020 May;
5(10).
PMID: 32434989
Immunotherapies that modulate T cell function have been firmly established as a pillar of cancer therapy, whereas the potential for B cells in the antitumor immune response is less established....