Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression

Overview

Journal Cancer Res

Specialty Oncology

Date 2024 Feb 8

PMID 38330147

Authors

Daniel J Zabransky

Yash Chhabra

Mitchell E Fane

Emma Kartalia

James M Leatherman

Laura Huser

Jacquelyn W Zimmerman

Daniel Delitto

Song Han

Todd D Armstrong

Soren Charmsaz

Samantha Guinn

Sneha Pramod

Elizabeth D Thompson

Steven J Hughes

Jennifer OConnell

Josephine M Egan

Elizabeth M Jaffee

Ashani T Weeraratna

Affiliations

Soon will be listed here.

Abstract

Significance: Aged pancreatic fibroblasts secrete GDF-15 and activate AKT signaling to promote pancreatic cancer growth, highlighting the critical role of aging-mediated changes in the pancreatic cancer microenvironment in driving tumor progression. See related commentary by Isaacson et al., p. 1185.

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