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Marian H Hettiaratchi

Explore the profile of Marian H Hettiaratchi including associated specialties, affiliations and a list of published articles. Areas
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Articles 25
Citations 391
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Recent Articles
1.
Wiggin N, Cook C, Black M, Cadena I, Rahal-Arabi S, Asnes C, et al.
Cell Mol Bioeng . 2024 Nov; 17(5):369-383. PMID: 39513011
Purpose: The primary aim of this study was to develop an open-source Python-based software for the automated analysis of dynamic cell behaviors in microphysiological models using non-confocal microscopy. This research...
2.
Dorogin J, Benz M, Moore C, Benoit D, Hettiaratchi M
Cell Mol Bioeng . 2024 Oct; 17(4):305-312. PMID: 39372554
Purpose: Affibodies are a class of versatile affinity proteins with a wide variety of therapeutic applications, ranging from contrast agents for imaging to cell-targeting therapeutics. We have identified several affibodies...
3.
Galindo A, Frey Rubio D, Hettiaratchi M
Mater Adv . 2024 May; 5(10):4025-4054. PMID: 38774837
Injury and disease in the central nervous system (CNS) can result in a dysregulated inflammatory environment that inhibits the repair of functional tissue. Biomaterials present a promising approach to tackle...
4.
Fosnacht K, Dorogin J, Jefferis P, Hettiaratchi M, Pluth M
Angew Chem Int Ed Engl . 2024 Apr; 63(24):e202402353. PMID: 38578835
Hydrogen sulfide (HS) is an important reactive sulfur species that is involved in many biological functions, and HS imbalances have been indicated as a potential biomarker for various diseases. Different...
5.
Mozipo E, Galindo A, Khachatourian J, Harris C, Dorogin J, Spaulding V, et al.
J Mater Chem B . 2024 Feb; 12(10):2523-2536. PMID: 38344905
Hydrazone-crosslinked hydrogels are attractive protein delivery vehicles for regenerative medicine. However, each regenerative medicine application requires unique hydrogel properties to achieve an ideal outcome. The properties of a hydrogel can...
6.
Mozipo E, Galindo A, Khachatourian J, Harris C, Dorogin J, Spaulding V, et al.
bioRxiv . 2023 Jul; PMID: 37503070
Hydrazone-crosslinked hydrogels are attractive protein delivery vehicles for regenerative medicine. However, each regenerative medicine application requires unique hydrogel properties to achieve an ideal outcome. The properties of a hydrogel can...
7.
Dorogin J, Hochstatter H, Shepherd S, Svendsen J, Benz M, Powers A, et al.
Adv Healthc Mater . 2023 Jun; 12(26):e2300793. PMID: 37379021
Uncontrolled bone morphogenetic protein-2 (BMP-2) release can lead to off-target bone growth and other adverse events. To tackle this challenge, yeast surface display is used to identify unique BMP-2-specific protein...
8.
Gilbert A, Newton T, Hettiaratchi M, Pluth M
Free Radic Biol Med . 2022 Aug; 190:148-157. PMID: 35940516
Reactive oxygen species (ROS) are important modulators of physiological signaling and play important roles in bone tissue regulation. Both reactive sulfur species (RSS) and reactive selenium species (RSeS) are involved...
9.
Teal C, Hettiaratchi M, Ho M, Ortin-Martinez A, Ganesh A, Pickering A, et al.
Adv Mater . 2022 Jul; 34(34):e2202612. PMID: 35790035
With the advent of increasingly complex combination strategies of biologics, independent control over their delivery is the key to their efficacy; however, current approaches are hindered by the limited independent...
10.
Priddy L, Krishnan L, Hettiaratchi M, Karthikeyakannan S, Gupte N, Guldberg R
J Orthop Res . 2022 Mar; 41(1):130-140. PMID: 35340049
Treatment of large bone defects with supraphysiological doses of bone morphogenetic protein-2 (BMP-2) has been associated with complications including heterotopic ossification (HO), inflammation, and pain, presumably due to poor spatiotemporal...