Tobias Bollenbach
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Explore the profile of Tobias Bollenbach including associated specialties, affiliations and a list of published articles.
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43
Citations
1695
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Recent Articles
11.
Qi Q, Angermayr S, Bollenbach T
Front Microbiol
. 2021 Nov;
12:760017.
PMID: 34745067
Understanding interactions between antibiotics used in combination is an important theme in microbiology. Using the interactions between the antifolate drug trimethoprim and the ribosome-targeting antibiotic erythromycin in as a model,...
12.
Ansmann G, Bollenbach T
PLoS Comput Biol
. 2021 Feb;
17(2):e1008635.
PMID: 33556059
Many ecological studies employ general models that can feature an arbitrary number of populations. A critical requirement imposed on such models is clone consistency: If the individuals from two populations...
13.
Kavcic B, Tkacik G, Bollenbach T
PLoS Comput Biol
. 2021 Jan;
17(1):e1008529.
PMID: 33411759
Phenomenological relations such as Ohm's or Fourier's law have a venerable history in physics but are still scarce in biology. This situation restrains predictive theory. Here, we build on bacterial...
14.
Kavcic B, Tkacik G, Bollenbach T
Nat Commun
. 2020 Aug;
11(1):4013.
PMID: 32782250
Antibiotics that interfere with translation, when combined, interact in diverse and difficult-to-predict ways. Here, we explain these interactions by "translation bottlenecks": points in the translation cycle where antibiotics block ribosomal...
15.
Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
Lukacisinova M, Fernando B, Bollenbach T
Nat Commun
. 2020 Jun;
11(1):3105.
PMID: 32561723
Genetic perturbations that affect bacterial resistance to antibiotics have been characterized genome-wide, but how do such perturbations interact with subsequent evolutionary adaptation to the drug? Here, we show that strong...
16.
Lukacisin M, Bollenbach T
Cell Syst
. 2019 Nov;
9(5):423-433.e3.
PMID: 31734160
Effective design of combination therapies requires understanding the changes in cell physiology that result from drug interactions. Here, we show that the genome-wide transcriptional response to combinations of two drugs,...
17.
Mitosch K, Rieckh G, Bollenbach T
Mol Syst Biol
. 2019 Feb;
15(2):e8470.
PMID: 30765425
Sudden stress often triggers diverse, temporally structured gene expression responses in microbes, but it is largely unknown how variable in time such responses are and if genes respond in the...
18.
de Vos M, Zagorski M, McNally A, Bollenbach T
Proc Natl Acad Sci U S A
. 2017 Sep;
114(40):10666-10671.
PMID: 28923953
Polymicrobial infections constitute small ecosystems that accommodate several bacterial species. Commonly, these bacteria are investigated in isolation. However, it is unknown to what extent the isolates interact and whether their...
19.
Zagorski M, Tabata Y, Brandenberg N, Lutolf M, Tkacik G, Bollenbach T, et al.
Science
. 2017 Jul;
356(6345):1379-1383.
PMID: 28663499
Like many developing tissues, the vertebrate neural tube is patterned by antiparallel morphogen gradients. To understand how these inputs are interpreted, we measured morphogen signaling and target gene expression in...
20.
Schwarz J, Bierbaum V, Vaahtomeri K, Hauschild R, Brown M, de Vries I, et al.
Curr Biol
. 2017 May;
27(9):1314-1325.
PMID: 28457871
Navigation of cells along gradients of guidance cues is a determining step in many developmental and immunological processes. Gradients can either be soluble or immobilized to tissues as demonstrated for...