Roy Kishony
Overview
Explore the profile of Roy Kishony including associated specialties, affiliations and a list of published articles.
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86
Citations
7205
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Recent Articles
1.
Gross R, Yelin I, Lazar V, Datta M, Kishony R
Nat Commun
. 2024 Jun;
15(1):5383.
PMID: 38918379
The incidence of beta-lactam resistance among clinical isolates is a major health concern. A key method to study the emergence of antibiotic resistance is adaptive laboratory evolution. However, in the...
2.
Poret A, Schaefers M, Merakou C, Mansour K, Lagoudas G, Cross A, et al.
bioRxiv
. 2024 Feb;
PMID: 38370793
Bacteria evolving within human hosts encounter selective tradeoffs that render mutations adaptive in one context and deleterious in another. Here, we report that the cystic fibrosis-associated pathogen overcomes in-human selective...
3.
Milman O, Yelin I, Kishony R
Nucleic Acids Res
. 2023 Jan;
51(2):553-573.
PMID: 36617974
Programmed chromosomal inversions allow bacteria to generate intra-population genotypic and functional heterogeneity, a bet-hedging strategy important in changing environments. Some programmed inversions modify coding sequences, producing different alleles in several...
4.
Shaer Tamar E, Kishony R
Nat Commun
. 2022 Dec;
13(1):7971.
PMID: 36577749
The evolutionary arms race between phages and bacteria, where bacteria evolve resistance to phages and phages retaliate with resistance-countering mutations, is a major driving force of molecular innovation and genetic...
5.
Lazar V, Snitser O, Barkan D, Kishony R
Nature
. 2022 Oct;
610(7932):540-546.
PMID: 36198788
The spread of antibiotic resistance is attracting increased attention to combination-based treatments. Although drug combinations have been studied extensively for their effects on bacterial growth, much less is known about...
6.
Gupta A, Zaman L, Strobel H, Gallie J, Burmeister A, Kerr B, et al.
Elife
. 2022 Jul;
11.
PMID: 35793223
During the struggle for survival, populations occasionally evolve new functions that give them access to untapped ecological opportunities. Theory suggests that coevolution between species can promote the evolution of such...
7.
Chung H, Merakou C, Schaefers M, Flett K, Martini S, Lu R, et al.
Nat Commun
. 2022 Mar;
13(1):1231.
PMID: 35264582
Acute bacterial infections are often treated empirically, with the choice of antibiotic therapy updated during treatment. The effects of such rapid antibiotic switching on the evolution of antibiotic resistance in...
8.
Levine-Tiefenbrun M, Yelin I, Alapi H, Herzel E, Kuint J, Chodick G, et al.
Nat Commun
. 2022 Mar;
13(1):1237.
PMID: 35246560
The BNT162b2 COVID-19 vaccine has been shown to reduce viral load of breakthrough infections (BTIs), an important factor affecting infectiousness. This viral-load protective effect has been waning with time post...
9.
Stracy M, Snitser O, Yelin I, Amer Y, Parizade M, Katz R, et al.
Science
. 2022 Feb;
375(6583):889-894.
PMID: 35201862
Treatment of bacterial infections currently focuses on choosing an antibiotic that matches a pathogen's susceptibility, with less attention paid to the risk that even susceptibility-matched treatments can fail as a...
10.
Levine-Tiefenbrun M, Yelin I, Uriel H, Kuint J, Schreiber L, Herzel E, et al.
J Mol Diagn
. 2021 Nov;
24(2):112-119.
PMID: 34826637
Quantifying the detection rate of the widely used quantitative RT-PCR (RT-qPCR) test for severe acute respiratory syndrome coronavirus 2 and its dependence on patient demographic characteristics and disease progression is...