Timothy Sharpe
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Explore the profile of Timothy Sharpe including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
399
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Recent Articles
1.
Loureiro J, Vacchini A, Berloffa G, Devan J, Schaefer V, Nosi V, et al.
Front Immunol
. 2025 Mar;
16:1519128.
PMID: 40040716
The TCR-mediated activation of T cells expressing the TCR Vγ9Vδ2 relies on an innate-like mechanism involving the butyrophilin 3A1, 3A2 and 2A1 molecules and phospho-antigens, without the participation of classical...
2.
Abel A, Muhlethaler T, Dessin C, Schachtsiek T, Sammet B, Sharpe T, et al.
J Biol Chem
. 2024 May;
300(6):107363.
PMID: 38735475
Cryptophycins are microtubule-targeting agents (MTAs) that belong to the most potent antimitotic compounds known to date; however, their exact molecular mechanism of action remains unclear. Here, we present the 2.2 ...
3.
Abiko L, Teixeira R, Engilberge S, Grahl A, Muhlethaler T, Sharpe T, et al.
Nat Chem
. 2022 Aug;
14(10):1133-1141.
PMID: 35953642
Recent high-pressure NMR results indicate that the preactive conformation of the β-adrenergic receptor (βAR) harbours completely empty cavities of ~100 Å volume, which disappear in the active conformation of the...
4.
Collu G, Bierig T, Krebs A, Engilberge S, Varma N, Guixa-Gonzalez R, et al.
Structure
. 2021 Sep;
30(1):95-106.e7.
PMID: 34587504
Chimeric fusion proteins are essential tools for protein nanotechnology. Non-optimized protein-protein connections are usually flexible and therefore unsuitable as structural building blocks. Here we show that the ER/K motif, a...
5.
Cramer J, Aliu B, Jiang X, Sharpe T, Pang L, Hadorn A, et al.
ChemMedChem
. 2021 Jun;
16(15):2345-2353.
PMID: 34061468
The C-type lectin receptor DC-SIGN mediates interactions with envelope glycoproteins of many viruses such as SARS-CoV-2, ebola, and HIV and contributes to virus internalization and dissemination. In the context of...
6.
Li-Blatter X, Zweifel L, Sharpe T
Methods Mol Biol
. 2021 Apr;
2263:47-79.
PMID: 33877593
The interaction of hen egg white lysozyme with the trisaccharide tri-N-acetyl glucosamine has been well-characterized by biophysical methods and structural biology. In this chapter, we present a series of experiments...
7.
Mas G, Burmann B, Sharpe T, Claudi B, Bumann D, Hiller S
Sci Adv
. 2020 Oct;
6(43).
PMID: 33087350
The homotrimeric molecular chaperone Skp of Gram-negative bacteria facilitates the transport of outer membrane proteins across the periplasm. It has been unclear how its activity is modulated during its functional...
8.
Grahl A, Abiko L, Isogai S, Sharpe T, Grzesiek S
Nat Commun
. 2020 May;
11(1):2216.
PMID: 32371991
Signal transmission and regulation of G-protein-coupled receptors (GPCRs) by extra- and intracellular ligands occurs via modulation of complex conformational equilibria, but their exact kinetic details and underlying atomic mechanisms are...
9.
Fiedler T, Ndinyanka Fabrice T, Studer V, Vinet A, Faltova L, Kammerer R, et al.
FEBS Lett
. 2020 Apr;
PMID: 32298460
Coronin proteins are widely expressed among eukaryotic organisms. Most coronins consist of a WD-repeat domain followed by a C-terminal coiled coil. Dictyostelium discoideum expresses a single short coronin coronin A,...
10.
Luther A, Urfer M, Zahn M, Muller M, Wang S, Mondal M, et al.
Nature
. 2019 Nov;
576(7786):E5.
PMID: 31758154
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.