Timothy E OSullivan
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Explore the profile of Timothy E OSullivan including associated specialties, affiliations and a list of published articles.
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40
Citations
2701
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Recent Articles
1.
De Siqueira M, Li G, Zhao Y, Wang S, Ahn I, Tamboline M, et al.
Cell Rep
. 2024 Nov;
43(12):114945.
PMID: 39579770
Adipose tissue regulates energy homeostasis and metabolic function, but its adaptability is impaired in obesity. In this study, we investigate the impact of acute PPARγ agonist treatment in obese mice...
2.
Hermans L, OSullivan T
J Exp Med
. 2024 May;
221(7).
PMID: 38713202
A method to precisely determine which cells respond to chemokines in vivo is currently lacking. A novel class of dual fluorescence reporter mice could help identify cells that produce and/or...
3.
Li J, Zhou A, Lee C, Shah S, Ji J, Senthilkumar V, et al.
Nat Immunol
. 2024 Apr;
25(5):928.
PMID: 38641722
No abstract available.
4.
Li J, Zhou A, Lee C, Shah S, Ji J, Senthilkumar V, et al.
Nat Immunol
. 2024 Apr;
25(5):778-789.
PMID: 38589619
Natural killer (NK) cells are a critical first line of defense against viral infection. Rare mutations in a small subset of transcription factors can result in decreased NK cell numbers...
5.
Hermans L, OSullivan T
Immunol Rev
. 2024 Mar;
323(1):61-79.
PMID: 38426615
NK cells are short-lived innate lymphocytes that can mediate antigen-independent responses to infection and cancer. However, studies from the past two decades have shown that NK cells can acquire transcriptional...
6.
Li R, Galindo C, Davidson D, Guo H, Zhong M, Qian J, et al.
Cell Rep
. 2024 Feb;
43(3):113800.
PMID: 38386559
Infection of mice by mouse cytomegalovirus (MCMV) triggers activation and expansion of Ly49H natural killer (NK) cells, which are virus specific and considered to be "adaptive" or "memory" NK cells....
7.
Adipose cDC1s contribute to obesity-associated inflammation through STING-dependent IL-12 production
Hildreth A, Padilla E, Gupta M, Wong Y, Sun R, Legala A, et al.
Nat Metab
. 2023 Nov;
5(12):2237-2252.
PMID: 37996702
Obesity is associated with chronic low-grade white adipose tissue (WAT) inflammation that can contribute to the development of insulin resistance in mammals. Previous studies have identified interleukin (IL)-12 as a...
8.
Schuster I, Sng X, Lau C, Powell D, Weizman O, Fleming P, et al.
Immunity
. 2023 Sep;
56(9):2173-2174.
PMID: 37703831
No abstract available.
9.
Li J, Hepworth M, OSullivan T
Immunity
. 2023 Jun;
56(6):1168-1186.
PMID: 37315533
Recent studies have demonstrated that tissue homeostasis and metabolic function are dependent on distinct tissue-resident immune cells that form functional cell circuits with structural cells. Within these cell circuits, immune...
10.
Cheng M, Li J, Riggan L, Chen B, Tafti R, Chin S, et al.
Nat Immunol
. 2023 Mar;
24(5):780-791.
PMID: 36928413
Viral infection outcomes are sex biased, with males generally more susceptible than females. Paradoxically, the numbers of antiviral natural killer (NK) cells are increased in males. We demonstrate that while...