Andrew D Hildreth
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Explore the profile of Andrew D Hildreth including associated specialties, affiliations and a list of published articles.
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10
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288
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Recent Articles
1.
De Siqueira M, Li G, Zhao Y, Wang S, Ahn I, Tamboline M, et al.
Cell Rep
. 2024 Nov;
43(12):114945.
PMID: 39579770
Adipose tissue regulates energy homeostasis and metabolic function, but its adaptability is impaired in obesity. In this study, we investigate the impact of acute PPARγ agonist treatment in obese mice...
2.
Adipose cDC1s contribute to obesity-associated inflammation through STING-dependent IL-12 production
Hildreth A, Padilla E, Gupta M, Wong Y, Sun R, Legala A, et al.
Nat Metab
. 2023 Nov;
5(12):2237-2252.
PMID: 37996702
Obesity is associated with chronic low-grade white adipose tissue (WAT) inflammation that can contribute to the development of insulin resistance in mammals. Previous studies have identified interleukin (IL)-12 as a...
3.
Hildreth A, Padilla E, Tafti R, Legala A, OSullivan T
Cell Rep
. 2023 Feb;
42(2):112141.
PMID: 36807146
Tissue-resident immune cells are critical to the initiation and potentiation of inflammation. However, the tissue-protective cellular communication networks initiated by resident immunity during sterile inflammation are not well understood. Using...
4.
Hildreth A, Ma F, Wong Y, Sun R, Pellegrini M, OSullivan T
Nat Immunol
. 2021 Apr;
22(5):639-653.
PMID: 33907320
White adipose tissue (WAT) is an essential regulator of energy storage and systemic metabolic homeostasis. Regulatory networks consisting of immune and structural cells are necessary to maintain WAT metabolism, which...
5.
Hildreth A, Riggan L, OSullivan T
STAR Protoc
. 2020 Dec;
1(3):100113.
PMID: 33377009
CRISPR-Cas9 genome engineering can be used to functionally investigate the complex mechanisms of immune system regulation. Decades of work have aimed to genetically reprogram innate immunity, but current approaches are...
6.
Riggan L, Hildreth A, Rolot M, Wong Y, Satyadi W, Sun R, et al.
Cell Rep
. 2020 May;
31(7):107651.
PMID: 32433960
CRISPR genome engineering has become a powerful tool to functionally investigate the complex mechanisms of immune system regulation. While decades of work have aimed to genetically reprogram innate immunity, the...
7.
Nabekura T, Riggan L, Hildreth A, OSullivan T, Shibuya A
Immunity
. 2019 Dec;
52(1):96-108.e9.
PMID: 31810881
Although type 1 innate lymphoid cells (ILC1s) have been originally found as liver-resident ILCs, their pathophysiological role in the liver remains poorly investigated. Here, we demonstrated that carbon tetrachloride (CCl)...
8.
Fields F, Freed S, Carothers K, Hamid M, Hammers D, Ross J, et al.
Drug Dev Res
. 2019 Sep;
81(1):43-51.
PMID: 31483516
Bacteriocins, the ribosomally produced antimicrobial peptides of bacteria, represent an untapped source of promising antibiotic alternatives. However, bacteriocins display diverse mechanisms of action, a narrow spectrum of activity, and inherent...
9.
Weizman O, Song E, Adams N, Hildreth A, Riggan L, Krishna C, et al.
Nat Immunol
. 2019 Jul;
20(8):1004-1011.
PMID: 31263280
Innate lymphoid cells (ILCs) are tissue-resident sentinels that are essential for early host protection from pathogens at initial sites of infection. However, whether pathogen-derived antigens directly modulate the responses of...
10.
Hildreth A, OSullivan T
Viruses
. 2019 Mar;
11(3).
PMID: 30893756
Infection is restrained by the concerted activation of tissue-resident and circulating immune cells. Recent discoveries have demonstrated that tissue-resident lymphocyte subsets, comprised of innate lymphoid cells (ILCs) and unconventional T...