Thomas Vorherr
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Explore the profile of Thomas Vorherr including associated specialties, affiliations and a list of published articles.
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12
Citations
55
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Recent Articles
1.
Jones M, Grosche P, Floersheimer A, Andre J, Gattlen R, Oser D, et al.
Biochemistry
. 2023 Mar;
62(7):1321-1329.
PMID: 36883372
The Myb transcription factor is involved in the proliferation of hematopoietic cells, and deregulation of its expression can lead to cancers such as leukemia. Myb interacts with various proteins, including...
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Mesrouze Y, Aguilar G, Bokhovchuk F, Martin T, Delaunay C, Villard F, et al.
Sci Rep
. 2020 Oct;
10(1):17442.
PMID: 33060790
The most downstream elements of the Hippo pathway, the TEAD transcription factors, are regulated by several cofactors, such as Vg/VGLL1-3. Earlier findings on human VGLL1 and here on human VGLL3...
4.
Karatas H, Maric T, DAlessandro P, Yevtodiyenko A, Vorherr T, Hollingworth G, et al.
ACS Chem Biol
. 2019 Sep;
14(10):2197-2205.
PMID: 31498986
Peptides constitute an important class of drugs for the treatment of multiple metabolic, oncological, and neurodegenerative diseases, and several hundred novel therapeutic peptides are currently in the preclinical and clinical...
5.
Leroux M, Vorherr T, Lewis I, Schaefer M, Koch G, Karaghiosoff K, et al.
Angew Chem Int Ed Engl
. 2019 Apr;
58(24):8231-8234.
PMID: 30946517
We report a new late-stage functionalization of small peptides and cyclopeptides relying on the Negishi cross-coupling of readily prepared iodotyrosine- or iodophenylalanine-containing peptides with aryl-, heteroaryl-, and alkylzinc pivalates or...
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Vorherr T, Lewis I, Berghausen J, Desrayaud S, Schaefer M
Int J Pept Res Ther
. 2018 Mar;
24(1):35-48.
PMID: 29527142
Abstract: Recently, a variety of studies concerned with the permeability and oral bioavailability of cyclic peptides have been reported. In particular, strategies aiming at modifying peptides to maintain or to...
8.
Scarabelli S, Tan K, Griss R, Hovius R, DAlessandro P, Vorherr T, et al.
ACS Sens
. 2017 Aug;
2(8):1191-1197.
PMID: 28766337
We are introducing a new approach to evaluate cellular uptake of drugs and drug candidates into living cells. The approach is based on converting the protein target of a given...
9.
Wallbrecher R, Chene P, Ruetz S, Stachyra T, Vorherr T, Brock R
Br J Pharmacol
. 2017 Apr;
174(16):2613-2622.
PMID: 28436014
Background And Purpose: Helix stapling enhances the activity of peptides that interact with a target protein in a helical conformation. These staples are also supposed to change the pharmacokinetics of...
10.
DAlessandro P, Buschmann N, Kaufmann M, Furet P, Baysang F, Brunner R, et al.
Angew Chem Int Ed Engl
. 2016 Nov;
55(52):16026-16030.
PMID: 27874234
To study the behavior of MDM2-p53 inhibitors in a disease-relevant cellular model, we have developed and validated a set of bioorthogonal probes that can be fluorescently labeled in cells and...