Thomas U Schwartz
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Explore the profile of Thomas U Schwartz including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Cruz V, Demircioglu F, Schwartz T
J Mol Biol
. 2020 Oct;
432(23):6028-6041.
PMID: 33058875
Linker of nucleoskeleton and cytoskeleton (LINC) complexes are molecular tethers that span the nuclear envelope (NE) and physically connect the nucleus to the cytoskeleton. They transmit mechanical force across the...
12.
Cheloha R, Harmand T, Wijne C, Schwartz T, Ploegh H
J Biol Chem
. 2020 Sep;
295(45):15307-15327.
PMID: 32868455
Reagents that bind tightly and specifically to biomolecules of interest remain essential in the exploration of biology and in their ultimate application to medicine. Besides ligands for receptors of known...
13.
Sonn-Segev A, Belacic K, Bodrug T, Young G, VanderLinden R, Schulman B, et al.
Nat Commun
. 2020 Apr;
11(1):1772.
PMID: 32286308
Sample purity is central to in vitro studies of protein function and regulation, and to the efficiency and success of structural studies using techniques such as x-ray crystallography and cryo-electron...
14.
Demircioglu F, Zheng W, McQuown A, Maier N, Watson N, Cheeseman I, et al.
Nat Commun
. 2019 Jul;
10(1):3262.
PMID: 31332180
TorsinA is an ER-resident AAA + ATPase, whose deletion of glutamate E303 results in the genetic neuromuscular disease primary dystonia. TorsinA is an unusual AAA + ATPase that needs an...
15.
Cruz V, Schwartz T
Methods Mol Biol
. 2018 Aug;
1840:17-23.
PMID: 30141034
Recombinant expression of proteins and their complexes is the routine laboratory procedure to generate pure reagents for biochemical and structural studies. Here we present the standard procedure developed in our...
16.
Onischenko E, Tang J, Andersen K, Knockenhauer K, Vallotton P, Derrer C, et al.
Cell
. 2017 Oct;
171(4):904-917.e19.
PMID: 29033133
Nuclear pore complexes (NPCs) are ∼100 MDa transport channels assembled from multiple copies of ∼30 nucleoporins (Nups). One-third of these Nups contain phenylalanine-glycine (FG)-rich repeats, forming a diffusion barrier, which...
17.
Hanke L, Schmidt F, Knockenhauer K, Morin B, Whelan S, Schwartz T, et al.
EMBO Rep
. 2017 Apr;
18(6):1027-1037.
PMID: 28396572
The transcription and replication machinery of negative-stranded RNA viruses presents a possible target for interference in the viral life cycle. We demonstrate the validity of this concept through the use...
18.
Hanke L, Knockenhauer K, Brewer R, van Diest E, Schmidt F, Schwartz T, et al.
mBio
. 2016 Dec;
7(6).
PMID: 27965447
Importance: Influenza virus strains can rapidly escape from protection afforded by seasonal vaccines or acquire resistance to available drugs. Additional ways to interfere with the virus life cycle are therefore...
19.
Lawrence K, Tapley E, Cruz V, Li Q, Aung K, Hart K, et al.
J Cell Biol
. 2016 Dec;
215(6):801-821.
PMID: 27956467
The Caenorhabditis elegans SUN domain protein, UNC-84, functions in nuclear migration and anchorage in the soma. We discovered a novel role for UNC-84 in DNA damage repair and meiotic recombination....
20.
Saxton R, Knockenhauer K, Schwartz T, Sabatini D
Sci Signal
. 2016 Sep;
9(446):ra92.
PMID: 27649739
Sestrin2 is a GATOR2-interacting protein that directly binds leucine and is required for the inhibition of mTORC1 under leucine deprivation, indicating that it is a leucine sensor for the mTORC1...