James R Partridge
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Explore the profile of James R Partridge including associated specialties, affiliations and a list of published articles.
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12
Citations
386
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Recent Articles
1.
Wallace K, Gerstenberg T, Ennis C, Perez-Bermejo J, Partridge J, Bandoro C, et al.
Mol Ther
. 2025 Mar;
PMID: 40022449
β-Hemoglobinopathies are common monogenic disorders. In sickle cell disease (SCD), a single mutation in the β-globin (HBB) gene results in dysfunctional hemoglobin protein, while in β-thalassemia, over 300 mutations distributed...
2.
Kerrigan J, Thomsen N, Cernijenko A, Kochanek S, Dewhurst J, OBrien G, et al.
J Med Chem
. 2024 Nov;
67(22):20682-20694.
PMID: 39541509
Sickle cell disease (SCD) is a prevalent, life-threatening condition with few treatment options, attributed to a heritable mutation in β-hemoglobin. Therapeutic induction of fetal hemoglobin (HbF) with small molecules has...
3.
Perez-Bermejo J, Efagene O, Matern W, Holden J, Kabir S, Chew G, et al.
Nat Commun
. 2024 Mar;
15(1):2625.
PMID: 38521763
Homology Directed Repair (HDR) enables precise genome editing, but the implementation of HDR-based therapies is hindered by limited efficiency in comparison to methods that exploit alternative DNA repair routes, such...
4.
Partridge J, Choy R, Silva-Garcia A, Yu C, Li Z, Sham H, et al.
J Struct Biol
. 2019 Mar;
206(2):170-182.
PMID: 30876891
Plasma kallikrein (pKal) is a serine protease responsible for cleaving high-molecular-weight kininogen to produce the pro-inflammatory peptide, bradykinin. Unregulated pKal activity can lead to hereditary angioedema (HAE) following excess bradykinin...
5.
Dementiev A, Silva A, Yee C, Li Z, Flavin M, Sham H, et al.
Blood Adv
. 2018 Mar;
2(5):549-558.
PMID: 29519898
Activated factor XIIa (FXIIa) is a serine protease that has received a great deal of interest in recent years as a potential target for the development of new antithrombotics. Despite...
6.
Metcalf B, Chuang C, Dufu K, Patel M, Silva-Garcia A, Johnson C, et al.
ACS Med Chem Lett
. 2017 Mar;
8(3):321-326.
PMID: 28337324
We report the discovery of a new potent allosteric effector of sickle cell hemoglobin, GBT440 (), that increases the affinity of hemoglobin for oxygen and consequently inhibits its polymerization when...
7.
Partridge J, Lavery L, Elnatan D, Naber N, Cooke R, Agard D
Elife
. 2014 Dec;
3.
PMID: 25531069
Hsp90 is a conserved chaperone that facilitates protein homeostasis. Our crystal structure of the mitochondrial Hsp90, TRAP1, revealed an extension of the N-terminal β-strand previously shown to cross between protomers...
8.
Ulrich A, Partridge J, Schwartz T
Mol Biol Cell
. 2014 Feb;
25(9):1484-92.
PMID: 24574455
The nuclear pore complex (NPC) regulates transport between the nucleus and cytoplasm. Soluble cargo-protein complexes navigate through the pore by binding to phenylalanine-glycine (FG)-repeat proteins attached to the channel walls....
9.
Lavery L, Partridge J, Ramelot T, Elnatan D, Kennedy M, Agard D
Mol Cell
. 2014 Jan;
53(2):330-43.
PMID: 24462206
While structural symmetry is a prevailing feature of homo-oligomeric proteins, asymmetry provides unique mechanistic opportunities. We present the crystal structure of full-length TRAP1, the mitochondrial Hsp90 molecular chaperone, in a...
10.
Alexander L, Partridge J, Agard D, McAlpine S
Bioorg Med Chem Lett
. 2011 Oct;
21(23):7068-71.
PMID: 22014826
Described is the synthesis of three different fluorescein-tagged derivatives of a macrocycle, and their binding affinity to heat shock protein 90 (Hsp90). Using fluorescence polarization anisotropy, we report the binding...