Thomas Thykjaer
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Explore the profile of Thomas Thykjaer including associated specialties, affiliations and a list of published articles.
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17
Citations
1218
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Recent Articles
1.
Moore F, Naamane N, Colli M, Bouckenooghe T, Ortis F, Gurzov E, et al.
J Biol Chem
. 2010 Oct;
286(2):929-41.
PMID: 20980260
Cytokines produced by islet-infiltrating immune cells induce β-cell apoptosis in type 1 diabetes. The IFN-γ-regulated transcription factors STAT1/IRF-1 have apparently divergent effects on β-cells. Thus, STAT1 promotes apoptosis and inflammation,...
2.
Ortis F, Naamane N, Flamez D, Ladriere L, Moore F, Cunha D, et al.
Diabetes
. 2009 Nov;
59(2):358-74.
PMID: 19934004
Objective: Cytokines contribute to pancreatic beta-cell death in type 1 diabetes. This effect is mediated by complex gene networks that remain to be characterized. We presently utilized array analysis to...
3.
Herbsleb M, Birkenkamp-Demtroder K, Thykjaer T, Wiuf C, Hein A, Orntoft T, et al.
BMC Med Genomics
. 2008 Jul;
1:31.
PMID: 18647386
Background: Mechanisms underlying the malignant development in bladder cancer are still not well understood. Lipolysis stimulated lipoprotein receptor (LSR) has previously been found to be upregulated by P53. Furthermore, we...
4.
Herbsleb M, Christensen O, Thykjaer T, Wiuf C, Borre M, Orntoft T, et al.
BMC Cancer
. 2008 Feb;
8:37.
PMID: 18237400
Background: Carcinoma in situ (CIS) is believed to be a precursor of invasive bladder cancer. Identification of CIS is a valuable prognostic factor since radical treatment strategies can be offered...
5.
Kruhoffer M, Dyrskjot L, Voss T, Lindberg R, Wyrich R, Thykjaer T, et al.
J Mol Diagn
. 2007 Aug;
9(4):452-8.
PMID: 17690207
We have developed a procedure for isolation of microRNA and genomic DNA in addition to total RNA from whole blood stabilized in PAXgene Blood RNA tubes. The procedure is based...
6.
Aaboe M, Birkenkamp-Demtroder K, Wiuf C, Sorensen F, Thykjaer T, Sauter G, et al.
Cancer Res
. 2006 Apr;
66(7):3434-42.
PMID: 16585165
The human transcription factor SOX4 was 5-fold up-regulated in bladder tumors compared with normal tissue based on whole-genome expression profiling of 166 clinical bladder tumor samples and 27 normal urothelium...
7.
Enver T, Soneji S, Joshi C, Brown J, Iborra F, Orntoft T, et al.
Hum Mol Genet
. 2005 Sep;
14(21):3129-40.
PMID: 16159889
Human embryonic stem cell (HESC) lines vary in their characteristics and behaviour not only because they are derived from genetically outbred populations, but also because they may undergo progressive adaptation...
8.
Dyrskjot L, Zieger K, Kruhoffer M, Thykjaer T, Jensen J, Primdahl H, et al.
Clin Cancer Res
. 2005 Jun;
11(11):4029-36.
PMID: 15930337
Purpose: Cancer of the urinary bladder is a common malignant disease in the western countries. The majority of patients presents with superficial tumors with a high recurrence frequency, a minor...
9.
Ahmed Memon A, Sorensen B, Meldgaard P, Fokdal L, Thykjaer T, Nexo E
Clin Cancer Res
. 2005 Feb;
11(2 Pt 1):606-11.
PMID: 15701847
Purpose: The goal of this study was to identify proteins down-regulated during bladder cancer progression. Experimental Design: By using comparative proteome analysis and measurement of mRNA, we found a significant...
10.
Cheng J, Yoo C, Weisenberger D, Chuang J, Wozniak C, Liang G, et al.
Cancer Cell
. 2004 Aug;
6(2):151-8.
PMID: 15324698
The frequent silencing of tumor suppressor genes by altered cytosine methylation and chromatin structural changes makes this process an attractive target for epigenetic therapy. Here we show that zebularine, a...