Fabrice Moore
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Explore the profile of Fabrice Moore including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
1143
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Recent Articles
1.
Grieco F, Moore F, Vigneron F, Santin I, Villate O, Marselli L, et al.
Diabetologia
. 2013 Dec;
57(3):502-11.
PMID: 24352375
Aims/hypothesis: Cytotoxic T cells and macrophages contribute to beta cell destruction in type 1 diabetes at least in part through the production of cytokines such as IL-1β, IFN-γ and TNF-α....
2.
Central role and mechanisms of β-cell dysfunction and death in friedreich ataxia-associated diabetes
Cnop M, Igoillo-Esteve M, Rai M, Begu A, Serroukh Y, Depondt C, et al.
Ann Neurol
. 2013 Jan;
72(6):971-82.
PMID: 23280845
Objective: Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused in almost all cases by homozygosity for a GAA trinucleotide repeat expansion in the frataxin gene. Frataxin is a...
3.
Moore F, Santin I, Nogueira T, Gurzov E, Marselli L, Marchetti P, et al.
PLoS One
. 2012 Feb;
7(2):e31062.
PMID: 22347430
In the course of Type 1 diabetes pro-inflammatory cytokines (e.g., IL-1β, IFN-γ and TNF-α) produced by islet-infiltrating immune cells modify expression of key gene networks in β-cells, leading to local...
4.
Moore F, Cunha D, Mulder H, Eizirik D
Methods Mol Biol
. 2011 Dec;
820:179-94.
PMID: 22131032
Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by immune infiltration of the pancreatic islets resulting in an inflammatory reaction named insulitis and subsequent beta cell apoptosis. During...
5.
Santin I, Moore F, Colli M, Gurzov E, Marselli L, Marchetti P, et al.
Diabetes
. 2011 Oct;
60(12):3279-88.
PMID: 21984578
Objective: Genome-wide association studies allowed the identification of several associations between specific loci and type 1 diabetes (T1D). However, the mechanisms by which most candidate genes predispose to T1D remain...
6.
Barthson J, Germano C, Moore F, Maida A, Drucker D, Marchetti P, et al.
J Biol Chem
. 2011 Sep;
286(45):39632-43.
PMID: 21937453
Type 1 diabetes is characterized by local inflammation (insulitis) in the pancreatic islets causing β-cell loss. The mitochondrial pathway of apoptosis is regulated by the balance and interaction between Bcl-2...
7.
Arif S, Moore F, Marks K, Bouckenooghe T, Dayan C, Planas R, et al.
Diabetes
. 2011 Jun;
60(8):2112-9.
PMID: 21659501
Objective: CD4 T-cells secreting interleukin (IL)-17 are implicated in several human autoimmune diseases, but their role in type 1 diabetes has not been defined. To address the relevance of such...
8.
Petersen A, Smidt K, Magnusson N, Moore F, Egefjord L, Rungby J
APMIS
. 2011 Jan;
119(2):93-102.
PMID: 21208276
Zinc is essential for the crystallization of insulin in pancreatic β-cells and is thought to induce apoptosis in a dose-dependent manner, thereby regulating β-cell mass. Therefore, a tight intracellular regulation...
9.
Moore F, Naamane N, Colli M, Bouckenooghe T, Ortis F, Gurzov E, et al.
J Biol Chem
. 2010 Oct;
286(2):929-41.
PMID: 20980260
Cytokines produced by islet-infiltrating immune cells induce β-cell apoptosis in type 1 diabetes. The IFN-γ-regulated transcription factors STAT1/IRF-1 have apparently divergent effects on β-cells. Thus, STAT1 promotes apoptosis and inflammation,...
10.
Ortis F, Naamane N, Flamez D, Ladriere L, Moore F, Cunha D, et al.
Diabetes
. 2009 Nov;
59(2):358-74.
PMID: 19934004
Objective: Cytokines contribute to pancreatic beta-cell death in type 1 diabetes. This effect is mediated by complex gene networks that remain to be characterized. We presently utilized array analysis to...