Thomas J McLellan
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Explore the profile of Thomas J McLellan including associated specialties, affiliations and a list of published articles.
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10
Citations
158
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Recent Articles
1.
Modjarrad K, Che Y, Wu H, Cadima C, Muik A, Maddur M, et al.
NPJ Vaccines
. 2024 Nov;
9(1):229.
PMID: 39567521
As SARS-CoV-2 evolves, increasing in potential for greater transmissibility and immune escape, updated vaccines are needed to boost adaptive immunity to protect against COVID-19 caused by circulating strains. Here, we...
2.
Yu X, Plotnikova O, Bonin P, Subashi T, McLellan T, Dumlao D, et al.
Elife
. 2019 Oct;
8.
PMID: 31580259
Alanine-serine-cysteine transporter 2 (ASCT2, SLC1A5) is the primary transporter of glutamine in cancer cells and regulates the mTORC1 signaling pathway. The SLC1A5 function involves finely tuned orchestration of two domain...
3.
Rouet R, Thuma B, Roy M, Lintner N, Rubitski D, Finley J, et al.
J Am Chem Soc
. 2018 Apr;
140(21):6596-6603.
PMID: 29668265
CRISPR-Cas RNA-guided endonucleases hold great promise for disrupting or correcting genomic sequences through site-specific DNA cleavage and repair. However, the lack of methods for cell- and tissue-selective delivery currently limits...
4.
Cedervall P, Aulabaugh A, Geoghegan K, McLellan T, Pandit J
Proc Natl Acad Sci U S A
. 2015 Mar;
112(12):E1414-22.
PMID: 25775568
Phosphodiesterase 4 (PDE4) is an essential contributor to intracellular signaling and an important drug target. The four members of this enzyme family (PDE4A to -D) are functional dimers in which...
5.
Han S, Czerwinski R, Caspers N, Limburg D, Ding W, Wang H, et al.
Biochem J
. 2014 Mar;
460(2):211-22.
PMID: 24593284
ITK (interleukin-2-inducible T-cell kinase) is a critical component of signal transduction in T-cells and has a well-validated role in their proliferation, cytokine release and chemotaxis. ITK is an attractive target...
6.
Atkinson K, Beretta E, Brown J, Castrodad M, Chen Y, Cosgrove J, et al.
Bioorg Med Chem Lett
. 2011 Feb;
21(6):1621-5.
PMID: 21324691
A potent, small molecule inhibitor with a favorable pharmacokinetic profile to allow for sustained SCD inhibition in vivo was identified. Starting from a low MW acyl guanidine (5a), identified with...
7.
McLellan T, Marr E, Wondrack L, Subashi T, Aeed P, Han S, et al.
Acta Crystallogr D Biol Crystallogr
. 2009 Dec;
65(Pt 12):1270-82.
PMID: 19966413
A systematic analysis was undertaken to seek correlations between the integrity, purity and activity of 50S ribosomal subunit preparations from Deinococcus radiodurans and their ability to crystallize. Conditions of fermentation,...
8.
Simons S, McLellan T, Aeed P, Zaniewski R, Desbonnet C, Wondrack L, et al.
Anal Biochem
. 2009 Aug;
395(1):77-85.
PMID: 19646947
We have developed an affinity purification of the large ribosomal subunit from Deinococcus radiodurans that exploits its association with FLAG-tagged 30S subunits. Thus, capture is indirect so that no modification...
9.
Dumez E, Snaith J, Jackson R, McElroy A, Overington J, Wythes M, et al.
J Org Chem
. 2002 Jul;
67(14):4882-92.
PMID: 12098301
A generic macrocyclic peptide structure 2 was designed as a potential inhibitor of a range of proteinases, by using as a basis for the design the known structures of a...
10.
Kelly M, McLellan T, Rosner P
Anal Chem
. 2002 Jan;
74(1):1-9.
PMID: 11795774
Advances in biomolecular mass spectrometry (Bio-MS) have made this technique an invaluable tool for analytical chemists and biochemists alike. The applicability of Bio-MS approaches in drug discovery now encompasses in...