Paul A Aeed
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Explore the profile of Paul A Aeed including associated specialties, affiliations and a list of published articles.
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5
Citations
67
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Recent Articles
1.
McLellan T, Marr E, Wondrack L, Subashi T, Aeed P, Han S, et al.
Acta Crystallogr D Biol Crystallogr
. 2009 Dec;
65(Pt 12):1270-82.
PMID: 19966413
A systematic analysis was undertaken to seek correlations between the integrity, purity and activity of 50S ribosomal subunit preparations from Deinococcus radiodurans and their ability to crystallize. Conditions of fermentation,...
2.
Simons S, McLellan T, Aeed P, Zaniewski R, Desbonnet C, Wondrack L, et al.
Anal Biochem
. 2009 Aug;
395(1):77-85.
PMID: 19646947
We have developed an affinity purification of the large ribosomal subunit from Deinococcus radiodurans that exploits its association with FLAG-tagged 30S subunits. Thus, capture is indirect so that no modification...
3.
Aeed P, Young C, Nagiec M, Elhammer A
Antimicrob Agents Chemother
. 2008 Dec;
53(2):496-504.
PMID: 19047657
By using a detergent-washed membrane preparation, the interaction of the fungal natural product inhibitor aureobasidin A (AbA) with inositol phosphorylceramide synthase (IPC synthase) was studied by kinetic analysis of wild-type...
4.
Liu S, Mansour M, Dillman K, Perez J, Danley D, Aeed P, et al.
Proc Natl Acad Sci U S A
. 2008 Sep;
105(36):13309-14.
PMID: 18757755
The phosphodiesterases (PDEs) are metal ion-dependent enzymes that regulate cellular signaling by metabolic inactivation of the ubiquitous second messengers cAMP and cGMP. In this role, the PDEs are involved in...
5.
Aeed P, Sperry A, Young C, Nagiec M, Elhammer A
Biochemistry
. 2004 Jun;
43(26):8483-93.
PMID: 15222759
The effect of 26 different membrane-perturbing agents on the activity and phase distribution of inositol phosphorylceramide synthase (IPC synthase) activity in crude Candida albicans membranes was investigated. The nonionic detergents...