Eric S Marr
Overview
Explore the profile of Eric S Marr including associated specialties, affiliations and a list of published articles.
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14
Citations
296
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Recent Articles
1.
Ferruz N, Doerr S, Vanase-Frawley M, Zou Y, Chen X, Marr E, et al.
Sci Rep
. 2019 Apr;
9(1):6076.
PMID: 30967561
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
2.
Ferruz N, Doerr S, Vanase-Frawley M, Zou Y, Chen X, Marr E, et al.
Sci Rep
. 2018 Jan;
8(1):897.
PMID: 29343833
The recent increase in the number of X-ray crystal structures of G-protein coupled receptors (GPCRs) has been enabling for structure-based drug design (SBDD) efforts. These structures have revealed that GPCRs...
3.
Patel N, Schwarz J, Hou X, Hoover D, Xie L, Fliri A, et al.
J Med Chem
. 2013 Nov;
56(22):9180-91.
PMID: 24215237
Positive allosteric modulators ("potentiators") of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPAR) enhance excitatory neurotransmission and may improve the cognitive deficits associated with various neurological disorders. The dihydroisoxazole (DHI) series of AMPAR...
4.
Brown M, Mitton-Fry M, Arcari J, Barham R, Casavant J, Gerstenberger B, et al.
J Med Chem
. 2013 Jun;
56(13):5541-52.
PMID: 23755848
Herein we describe the structure-aided design and synthesis of a series of pyridone-conjugated monobactam analogues with in vitro antibacterial activity against clinically relevant Gram-negative species including Pseudomonas aeruginosa , Klebsiella...
5.
Liu S, Song X, Chrunyk B, Shanker S, Hoth L, Marr E, et al.
Nat Commun
. 2013 May;
4:1888.
PMID: 23695682
The constituent polypeptides of the interleukin-17 family form six different homodimeric cytokines (IL-17A-F) and the heterodimeric IL-17A/F. Their interactions with IL-17 receptors A-E (IL-17RA-E) mediate host defenses while also contributing...
6.
Magee T, Han S, McCurdy S, Nguyen T, Granskog K, Marr E, et al.
Bioorg Med Chem Lett
. 2013 Feb;
23(6):1727-31.
PMID: 23414806
A novel series of 3-O-carbamoyl erythromycin A derived analogs, labeled carbamolides, with activity versus resistant bacterial isolates of staphylococci (including macrolide and oxazolidinone resistant strains) and streptococci are reported. An...
7.
Helal C, Kang Z, Hou X, Pandit J, Chappie T, Humphrey J, et al.
J Med Chem
. 2011 Jun;
54(13):4536-47.
PMID: 21650160
Utilizing structure-based virtual library design and scoring, a novel chimeric series of phosphodiesterase 10A (PDE10A) inhibitors was discovered by synergizing binding site interactions and ADME properties of two chemotypes. Virtual...
8.
Han S, Zaniewski R, Marr E, Lacey B, Tomaras A, Evdokimov A, et al.
Proc Natl Acad Sci U S A
. 2010 Dec;
107(51):22002-7.
PMID: 21135211
Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen that causes nosocomial infections for which there are limited treatment options. Penicillin-binding protein PBP3, a key therapeutic target, is an essential enzyme responsible...
9.
McLellan T, Marr E, Wondrack L, Subashi T, Aeed P, Han S, et al.
Acta Crystallogr D Biol Crystallogr
. 2009 Dec;
65(Pt 12):1270-82.
PMID: 19966413
A systematic analysis was undertaken to seek correlations between the integrity, purity and activity of 50S ribosomal subunit preparations from Deinococcus radiodurans and their ability to crystallize. Conditions of fermentation,...
10.
Simons S, McLellan T, Aeed P, Zaniewski R, Desbonnet C, Wondrack L, et al.
Anal Biochem
. 2009 Aug;
395(1):77-85.
PMID: 19646947
We have developed an affinity purification of the large ribosomal subunit from Deinococcus radiodurans that exploits its association with FLAG-tagged 30S subunits. Thus, capture is indirect so that no modification...