Thomas E Wellems
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Explore the profile of Thomas E Wellems including associated specialties, affiliations and a list of published articles.
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102
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3794
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Recent Articles
1.
Kiboi D, Sa J, Nayak A, Micchelli C, Amin S, Burbelo A, et al.
Antimicrob Agents Chemother
. 2025 Feb;
69(3):e0005324.
PMID: 39927767
Artemisinin-based combination therapies (ACTs) are vital for malaria treatment, but these are threatened by blood-stage persisters-dormant forms of parasites that can survive drug exposure and cause recrudescent infections. Here, we...
2.
Micchelli C, Percopo C, Traver M, Brzostowski J, Amin S, Prigge S, et al.
PNAS Nexus
. 2024 Oct;
3(10):pgae424.
PMID: 39381646
Morphological modifications and shifts in organelle relationships are hallmarks of dormancy in eukaryotic cells. Communications between altered mitochondria and nuclei are associated with metabolic quiescence of cancer cells that can...
3.
Hazzard B, Sa J, Bogale H, Pascini T, Ellis A, Amin S, et al.
Nat Commun
. 2024 Sep;
15(1):7625.
PMID: 39223117
Most Plasmodium vivax infections contain genetically distinct parasites, but the consequences of this polyclonality on the development of asexual parasites, their sexual differentiation, and their transmission remain unknown. We describe...
4.
Gonzales-Wartz K, Sa J, Lee K, Gebremicale Y, Deng B, Long C, et al.
Parasit Vectors
. 2024 Jul;
17(1):290.
PMID: 38971776
Background: Aedes and Anopheles mosquitoes are responsible for tremendous global health burdens from their transmission of pathogens causing malaria, lymphatic filariasis, dengue, and yellow fever. Innovative vector control strategies will...
5.
Micchelli C, Percopo C, Traver M, Brzostowski J, Amin S, Prigge S, et al.
bioRxiv
. 2024 Feb;
PMID: 38410435
Morphological modifications and shifts in organelle relationships are hallmarks of dormancy in eukaryotic cells. Communications between altered mitochondria and nuclei are associated with metabolic quiescence of cancer cells that can...
6.
Hazzard B, Sa J, Bogale H, Pascini T, Ellis A, Amin S, et al.
Res Sq
. 2024 Feb;
PMID: 38410426
Most infections contain genetically distinct parasites, but the consequences of this polyclonality on the development of asexual parasites, their sexual differentiation, and their transmission remain unknown. We describe infections of...
7.
Esser L, Zhou F, Zeher A, Wu W, Huang R, Yu C, et al.
J Biol Chem
. 2023 May;
299(7):104860.
PMID: 37236355
Among the various components of the protozoan Plasmodium mitochondrial respiratory chain, only Complex III is a validated cellular target for antimalarial drugs. The compound CK-2-68 was developed to specifically target...
8.
Deng C, Wu W, Yuan Y, Li G, Zhang H, Zheng S, et al.
Open Forum Infect Dis
. 2023 Mar;
10(3):ofad076.
PMID: 36910690
Background: Mass drug administration (MDA) is a powerful tool for malaria control, but the medicines to use, dosing, number of rounds, and potential selection of drug resistance remain open questions....
9.
Hamid M, Abdelraheem M, Acheampong D, Ahouidi A, Ali M, Almagro-Garcia J, et al.
Wellcome Open Res
. 2023 Mar;
8:22.
PMID: 36864926
We describe the MalariaGEN Pf7 data resource, the seventh release of genome variation data from the MalariaGEN network. It comprises over 20,000 samples from 82 partner studies in 33 countries,...
10.
Singh B, Zhang C, Wu J, Peng Y, He X, Tumas K, et al.
Antimicrob Agents Chemother
. 2023 Jan;
67(2):e0082122.
PMID: 36625569
Protein ubiquitination is an important posttranslational regulation mechanism that mediates development and modifies parasite responses to antimalarial drugs. Although mutations in several parasite ubiquitination enzymes have been linked to increased...