Thomas E Wellems
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Explore the profile of Thomas E Wellems including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Hazzard B, Sa J, Ellis A, Pascini T, Amin S, Wellems T, et al.
PLoS Negl Trop Dis
. 2022 Dec;
16(12):e0010991.
PMID: 36525464
Plasmodium vivax infections often consist of heterogenous populations of parasites at different developmental stages and with distinct transcriptional profiles, which complicates gene expression analyses. The advent of single cell RNA...
12.
Adam I, Alam M, Alemu S, Amaratunga C, Amato R, Andrianaranjaka V, et al.
Wellcome Open Res
. 2022 Jun;
7:136.
PMID: 35651694
This report describes the MalariaGEN Pv4 dataset, a new release of curated genome variation data on 1,895 samples of collected at 88 worldwide locations between 2001 and 2017. It includes...
13.
Liu M, Guo G, Qian P, Mu J, Lu B, He X, et al.
Proc Natl Acad Sci U S A
. 2022 Feb;
119(9).
PMID: 35210361
5-methylcytosine (mC) is an important epitranscriptomic modification involved in messenger RNA (mRNA) stability and translation efficiency in various biological processes. However, it remains unclear if mC modification contributes to the...
14.
Ahouidi A, Ali M, Almagro-Garcia J, Amambua-Ngwa A, Amaratunga C, Amato R, et al.
Wellcome Open Res
. 2021 Jul;
6:42.
PMID: 33824913
MalariaGEN is a data-sharing network that enables groups around the world to work together on the genomic epidemiology of malaria. Here we describe a new release of curated genome variation...
15.
Moraes Barros R, Thawnashom K, Gibson T, Armistead J, Caleon R, Kaneko M, et al.
Malar J
. 2021 Jun;
20(1):247.
PMID: 34090438
Background: Plasmodium knowlesi is now the major cause of human malaria in Malaysia, complicating malaria control efforts that must attend to the elimination of multiple Plasmodium species. Recent advances in...
16.
Connelly S, Manzella-Lapeira J, Levine Z, Brzostowski J, Krymskaya L, Rahman R, et al.
mBio
. 2021 May;
12(3):e0075321.
PMID: 34044591
Artemisinin and its semisynthetic derivatives (ART) are fast acting, potent antimalarials; however, their use in malaria treatment is frequently confounded by recrudescences from bloodstream parasites that enter into and later...
17.
Coonahan E, Yang K, Pecic S, De Vos M, Wellems T, Fay M, et al.
Sci Transl Med
. 2021 Mar;
13(585).
PMID: 33731432
Tracking antimalarial drug use and efficacy is essential for monitoring the current spread of antimalarial drug resistance. However, available methods for determining tablet quality and patient drug use are often...
18.
Bogale H, Pascini T, Kanatani S, Sa J, Wellems T, Sinnis P, et al.
Proc Natl Acad Sci U S A
. 2021 Mar;
118(10).
PMID: 33653959
Despite the critical role of sporozoites in malaria transmission, we still know little about the mechanisms underlying their development in mosquitoes. Here, we use single-cell RNA sequencing to characterize the...
19.
Mu J, Yu L, Wellems T
Front Cell Infect Microbiol
. 2021 Jan;
10:620419.
PMID: 33505925
Rapid, reliable, and sensitive detection of infection is central to malaria control and elimination. Many Malaria Rapid Diagnostic Tests (RDTs) developed for this purpose depend upon immunoassays that can be...
20.
Ansbro M, Itkin Z, Chen L, Zahoranszky-Kohalmi G, Amaratunga C, Miotto O, et al.
ACS Pharmacol Transl Sci
. 2020 Dec;
3(6):1144-1157.
PMID: 33344893
The first-line treatments for uncomplicated malaria are artemisinin-based combination therapies (ACTs), consisting of an artemisinin derivative combined with a longer acting partner drug. However, the spread of with decreased susceptibility...