Thomas Bajaj
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Explore the profile of Thomas Bajaj including associated specialties, affiliations and a list of published articles.
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22
Citations
325
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Recent Articles
1.
Hartmann J, Klengel C, Dillmann L, Hisey E, Hafner K, Shukla R, et al.
Proc Natl Acad Sci U S A
. 2024 Dec;
121(52):e2417728121.
PMID: 39705315
Genes involved in regulating the hypothalamic-pituitary-adrenal (HPA) axis, including the glucocorticoid receptor (GR), are linked to various stress-related psychopathologies including bipolar disorder as well as other mood and trauma-related disorders....
2.
Bordes J, Bajaj T, Miranda L, van Doeselaar L, Brix L, Narayan S, et al.
Commun Biol
. 2024 Dec;
7(1):1684.
PMID: 39702524
Early life stress (ELS) can negatively impact health, increasing the risk of stress-related disorders, such as post-traumatic stress disorder (PTSD). Importantly, PTSD disproportionately affects women, emphasizing the critical need to...
3.
Mackert S, Niemeyer C, Mecdad Y, Ebert T, Bajaj T, Durand S, et al.
bioRxiv
. 2024 Dec;
PMID: 39677641
Depression is a stress-associated disorder, and it represents a major global health issue. Its pathophysiology is complex and remains insufficiently understood, with current medications often showing limited efficacy and undesirable...
4.
Hofer S, Daskalaki I, Bergmann M, Friscic J, Zimmermann A, Mueller M, et al.
Nat Cell Biol
. 2024 Aug;
26(9):1571-1584.
PMID: 39117797
Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model organisms and improve human health. The natural polyamine spermidine has been similarly linked to autophagy enhancement, geroprotection and...
5.
Bajaj T, Ebert T, Dillmann L, Sokn C, Gassen N, Hartmann J
Autophagy
. 2024 Jun;
20(11):2581-2583.
PMID: 38934263
A multitude of cellular responses to intrinsic and extrinsic signals converge on macroautophagy/autophagy, a conserved catabolic process that degrades cytoplasmic constituents and organelles in the lysosome, particularly during starvation or...
6.
Stepan J, Heinz D, Dethloff F, Wiechmann S, Martinelli S, Hafner K, et al.
Sci Signal
. 2024 Apr;
17(834):eadj6603.
PMID: 38687825
The localization, number, and function of postsynaptic AMPA-type glutamate receptors (AMPARs) are crucial for synaptic plasticity, a cellular correlate for learning and memory. The Hippo pathway member WWC1 is an...
7.
Hartmann J, Bajaj T, Otten J, Klengel C, Ebert T, Gellner A, et al.
Nat Commun
. 2024 Mar;
15(1):2635.
PMID: 38528004
High levels of proinflammatory cytokines induce neurotoxicity and catalyze inflammation-driven neurodegeneration, but the specific release mechanisms from microglia remain elusive. Here we show that secretory autophagy (SA), a non-lytic modality...
8.
Chatzinakos C, Pernia C, Morrison F, Iatrou A, McCullough K, Schuler H, et al.
Am J Psychiatry
. 2023 Jul;
180(10):739-754.
PMID: 37491937
Objective: Multidisciplinary studies of posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) implicate the dorsolateral prefrontal cortex (DLPFC) in disease risk and pathophysiology. Postmortem brain studies have relied on...
9.
Wen J, Zellner A, Braun N, Bajaj T, Gassen N, Peitz M, et al.
Transl Psychiatry
. 2023 May;
13(1):143.
PMID: 37137886
FIP200 plays important roles in homeostatic processes such as autophagy and signaling pathways such as focal adhesion kinase (FAK) signaling. Furthermore, genetic studies suggest an association of FIP200 mutations with...
10.
Hartmann J, Bajaj T, Otten J, Klengel C, Gellner A, Junglas E, et al.
bioRxiv
. 2023 Apr;
PMID: 37066393
High levels of proinflammatory cytokines induce neurotoxicity and catalyze inflammation-driven neurodegeneration, but the specific release mechanisms from microglia remain elusive. We demonstrate that secretory autophagy (SA), a non-lytic modality of...