Jakob Hartmann
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Explore the profile of Jakob Hartmann including associated specialties, affiliations and a list of published articles.
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45
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1414
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Recent Articles
1.
Hartmann J, Klengel C, Dillmann L, Hisey E, Hafner K, Shukla R, et al.
Proc Natl Acad Sci U S A
. 2024 Dec;
121(52):e2417728121.
PMID: 39705315
Genes involved in regulating the hypothalamic-pituitary-adrenal (HPA) axis, including the glucocorticoid receptor (GR), are linked to various stress-related psychopathologies including bipolar disorder as well as other mood and trauma-related disorders....
2.
Mackert S, Niemeyer C, Mecdad Y, Ebert T, Bajaj T, Durand S, et al.
bioRxiv
. 2024 Dec;
PMID: 39677641
Depression is a stress-associated disorder, and it represents a major global health issue. Its pathophysiology is complex and remains insufficiently understood, with current medications often showing limited efficacy and undesirable...
3.
Single-molecule dynamic structural biology with vertically arranged DNA on a fluorescence microscope
Szalai A, Ferrari G, Richter L, Hartmann J, Kesici M, Ji B, et al.
Nat Methods
. 2024 Nov;
22(1):135-144.
PMID: 39516563
The intricate interplay between DNA and proteins is key for biological functions such as DNA replication, transcription and repair. Dynamic nanoscale observations of DNA structural features are necessary for understanding...
4.
Bajaj T, Ebert T, Dillmann L, Sokn C, Gassen N, Hartmann J
Autophagy
. 2024 Jun;
20(11):2581-2583.
PMID: 38934263
A multitude of cellular responses to intrinsic and extrinsic signals converge on macroautophagy/autophagy, a conserved catabolic process that degrades cytoplasmic constituents and organelles in the lysosome, particularly during starvation or...
5.
Hartmann J, Bajaj T, Otten J, Klengel C, Ebert T, Gellner A, et al.
Nat Commun
. 2024 Mar;
15(1):2635.
PMID: 38528004
High levels of proinflammatory cytokines induce neurotoxicity and catalyze inflammation-driven neurodegeneration, but the specific release mechanisms from microglia remain elusive. Here we show that secretory autophagy (SA), a non-lytic modality...
6.
Ke S, Hartmann J, Ressler K, Liu Y, Koenen K
Brain Behav Immun
. 2023 Sep;
114:360-370.
PMID: 37689277
Posttraumatic stress disorder (PTSD) occurs in some people following exposure to a terrifying or catastrophic event involving actual/threatened death, serious injury, or sexual violence. PTSD is a common and debilitating...
7.
Chatzinakos C, Pernia C, Morrison F, Iatrou A, McCullough K, Schuler H, et al.
Am J Psychiatry
. 2023 Jul;
180(10):739-754.
PMID: 37491937
Objective: Multidisciplinary studies of posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) implicate the dorsolateral prefrontal cortex (DLPFC) in disease risk and pathophysiology. Postmortem brain studies have relied on...
8.
Bordes J, Miranda L, Reinhardt M, Narayan S, Hartmann J, Newman E, et al.
Nat Commun
. 2023 Jul;
14(1):4319.
PMID: 37463994
Severe stress exposure increases the risk of stress-related disorders such as major depressive disorder (MDD). An essential characteristic of MDD is the impairment of social functioning and lack of social...
9.
Hartmann J, Bajaj T, Otten J, Klengel C, Gellner A, Junglas E, et al.
bioRxiv
. 2023 Apr;
PMID: 37066393
High levels of proinflammatory cytokines induce neurotoxicity and catalyze inflammation-driven neurodegeneration, but the specific release mechanisms from microglia remain elusive. We demonstrate that secretory autophagy (SA), a non-lytic modality of...
10.
McCullough K, Katrinli S, Hartmann J, Lori A, Klengel C, Missig G, et al.
Transl Psychiatry
. 2022 Oct;
12(1):423.
PMID: 36192377
Exposure to stress triggers biological changes throughout the body. Accumulating evidence indicates that alterations in immune system function are associated with the development of stress-associated illnesses such as major depressive...