Claudia Klengel
Overview
Explore the profile of Claudia Klengel including associated specialties, affiliations and a list of published articles.
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12
Citations
121
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Recent Articles
1.
Hartmann J, Klengel C, Dillmann L, Hisey E, Hafner K, Shukla R, et al.
Proc Natl Acad Sci U S A
. 2024 Dec;
121(52):e2417728121.
PMID: 39705315
Genes involved in regulating the hypothalamic-pituitary-adrenal (HPA) axis, including the glucocorticoid receptor (GR), are linked to various stress-related psychopathologies including bipolar disorder as well as other mood and trauma-related disorders....
2.
Mackert S, Niemeyer C, Mecdad Y, Ebert T, Bajaj T, Durand S, et al.
bioRxiv
. 2024 Dec;
PMID: 39677641
Depression is a stress-associated disorder, and it represents a major global health issue. Its pathophysiology is complex and remains insufficiently understood, with current medications often showing limited efficacy and undesirable...
3.
Bronk G, Lardenoije R, Koolman L, Klengel C, Dan S, Howell B, et al.
bioRxiv
. 2024 Oct;
PMID: 39416061
Because DNA methylation changes reliably with age, machine learning models called epigenetic clocks can estimate an individual's age based on their DNA methylation profile. This epigenetic measure of age can...
4.
Maddox S, Ponomareva O, Zaleski C, Chen M, Vella K, Hollenberg A, et al.
Mol Psychiatry
. 2024 Jul;
30(1):201-212.
PMID: 39039155
The amygdala is an established site for fear memory formation, and clinical studies suggest involvement of hormone signaling cascades in development of trauma-related disorders. While an association of thyroid hormone...
5.
Hartmann J, Bajaj T, Otten J, Klengel C, Ebert T, Gellner A, et al.
Nat Commun
. 2024 Mar;
15(1):2635.
PMID: 38528004
High levels of proinflammatory cytokines induce neurotoxicity and catalyze inflammation-driven neurodegeneration, but the specific release mechanisms from microglia remain elusive. Here we show that secretory autophagy (SA), a non-lytic modality...
6.
Hartmann J, Bajaj T, Otten J, Klengel C, Gellner A, Junglas E, et al.
bioRxiv
. 2023 Apr;
PMID: 37066393
High levels of proinflammatory cytokines induce neurotoxicity and catalyze inflammation-driven neurodegeneration, but the specific release mechanisms from microglia remain elusive. We demonstrate that secretory autophagy (SA), a non-lytic modality of...
7.
Narendra S, Klengel C, Hamzeh B, Patel D, Otten J, Lardenoije R, et al.
Transl Psychiatry
. 2022 Nov;
12(1):476.
PMID: 36371333
Repeated excessive alcohol consumption is a risk factor for alcohol use disorder (AUD). Although AUD has been more common in men than women, women develop more severe behavioral and physical...
8.
McCullough K, Katrinli S, Hartmann J, Lori A, Klengel C, Missig G, et al.
Transl Psychiatry
. 2022 Oct;
12(1):423.
PMID: 36192377
Exposure to stress triggers biological changes throughout the body. Accumulating evidence indicates that alterations in immune system function are associated with the development of stress-associated illnesses such as major depressive...
9.
Hartmann J, Bajaj T, Klengel C, Chatzinakos C, Ebert T, Dedic N, et al.
Cell Rep
. 2021 Jun;
35(9):109185.
PMID: 34077736
Responding to different dynamic levels of stress is critical for mammalian survival. Disruption of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) signaling is proposed to underlie hypothalamic-pituitary-adrenal (HPA) axis dysregulation...
10.
Huckins L, Chatzinakos C, Breen M, Hartmann J, Klengel T, da Silva Almeida A, et al.
Cell Rep
. 2020 Jun;
31(9):107716.
PMID: 32492425
To reveal post-traumatic stress disorder (PTSD) genetic risk influences on tissue-specific gene expression, we use brain and non-brain transcriptomic imputation. We impute genetically regulated gene expression (GReX) in 29,539 PTSD...