Thijn R Brummelkamp
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Explore the profile of Thijn R Brummelkamp including associated specialties, affiliations and a list of published articles.
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13099
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Recent Articles
11.
van Ruiten M, van Gent D, Sedeno Cacciatore A, Fauster A, Willems L, Hekkelman M, et al.
Nat Struct Mol Biol
. 2022 Jun;
29(6):586-591.
PMID: 35710836
Cohesin structures the genome through the formation of chromatin loops and by holding together the sister chromatids. The acetylation of cohesin's SMC3 subunit is a dynamic process that involves the...
12.
Landskron L, Bak J, Adamopoulos A, Kaplani K, Moraiti M, van den Hengel L, et al.
Science
. 2022 Apr;
376(6595):eabn6020.
PMID: 35482892
The detyrosination-tyrosination cycle involves the removal and religation of the C-terminal tyrosine of α-tubulin and is implicated in cognitive, cardiac, and mitotic defects. The vasohibin-small vasohibin-binding protein (SVBP) complex underlies...
13.
Haarhuis J, van der Weide R, Blomen V, Flach K, Teunissen H, Willems L, et al.
Nat Commun
. 2022 Feb;
13(1):754.
PMID: 35136067
The genome consists of regions of transcriptionally active euchromatin and more silent heterochromatin. We reveal that the formation of heterochromatin domains requires cohesin turnover on DNA. Stabilization of cohesin on...
14.
Jongsma M, de Waard A, Raaben M, Zhang T, Cabukusta B, Platzer R, et al.
Immunity
. 2021 Feb;
54(2):387.
PMID: 33567263
No abstract available.
15.
Sarbanes S, Blomen V, Lam E, Heissel S, Luna J, Brummelkamp T, et al.
Proc Natl Acad Sci U S A
. 2021 Jan;
118(1).
PMID: 33443154
The journey from plasma membrane to nuclear pore is a critical step in the lifecycle of DNA viruses, many of which must successfully deposit their genomes into the nucleus for...
16.
Jongsma M, de Waard A, Raaben M, Zhang T, Cabukusta B, Platzer R, et al.
Immunity
. 2020 Dec;
54(1):132-150.e9.
PMID: 33271119
HLA class I (HLA-I) glycoproteins drive immune responses by presenting antigens to cognate CD8 T cells. This process is often hijacked by tumors and pathogens for immune evasion. Because options...
17.
De Zan E, van Stiphout R, Gapp B, Blomen V, Brummelkamp T, Nijman S
Sci Signal
. 2020 Sep;
13(649).
PMID: 32934076
Forward genetic screens in mammalian cell lines, such as RNAi and CRISPR-Cas9 screens, have made major contributions to the elucidation of diverse signaling pathways. Here, we exploited human haploid cells...
18.
Surface L, Burrow D, Li J, Park J, Kumar S, Lyu C, et al.
Sci Transl Med
. 2020 May;
12(544).
PMID: 32434850
Nitrogen-containing bisphosphonates (N-BPs), such as alendronate, are the most widely prescribed medications for diseases involving bone, with nearly 200 million prescriptions written annually. Recently, widespread use of N-BPs has been...
19.
Adamopoulos A, Landskron L, Heidebrecht T, Tsakou F, Bleijerveld O, Altelaar M, et al.
Nat Struct Mol Biol
. 2019 Jul;
26(7):567-570.
PMID: 31270470
The cyclic enzymatic removal and ligation of the C-terminal tyrosine of α-tubulin generates heterogeneous microtubules and affects their functions. Here we describe the crystal and solution structure of the tubulin...
20.
Luteijn R, van Diemen F, Blomen V, Boer I, Sadasivam S, van Kuppevelt T, et al.
J Virol
. 2019 Apr;
93(13).
PMID: 30996093
Vaccinia virus is a promising viral vaccine and gene delivery candidate and has historically been used as a model to study poxvirus-host cell interactions. We employed a genome-wide insertional mutagenesis...