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» Authors » Thierry Cresteil

Thierry Cresteil

Explore the profile of Thierry Cresteil including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 68
Citations 752
Followers 0
Related Specialties
Chemistry
Biochemistry
Pharmacology
Top 10 Co-Authors
Genevieve Aubert
Laure Eloy
Patrick Dallemagne
Sylviane Thoret
Christophe Rochais
Joelle Dubois
Jean-Pierre Majoral
Sylvain Rault
Nabil El Brahmi
Guy Lewin
Published In
Eur J Med Chem
Bioorg Med Chem
J Med Chem
Bioorg Med Chem Lett
Org Biomol Chem
Affiliations
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Recent Articles
1.
Targeting prohibitin with small molecules to promote melanogenesis and apoptosis in melanoma cells
Djehal A, Krayem M, Najem A, Hammoud H, Cresteil T, Nebigil C, et al.
Eur J Med Chem . 2018 Jul; 155:880-888. PMID: 29960207
Prohibitins 1 and 2 (PHB1/2) are scaffold proteins that are involved in both melanogenesis and oncogenic pathways. We hypothesized that a PHB1 ligand, melanogenin, may display anti-cancer effects in addition...
2.
First-in-Class Combination Therapy of a Copper(II) Metallo-Phosphorus Dendrimer with Cytotoxic Agents
Mignani S, El Brahmi N, Cresteil T, Majoral J
Oncology . 2018 Mar; 94(5):324-328. PMID: 29533961
The metallo-phosphorus dendrimer 1G3-Cu (generation 3 dendrimer bearing 48 conjugated copper(II) on its surface) has antiproliferative activity related to its capacity to activate Bax translocation. In the present study, we...
3.
Original Multivalent Gold(III) and Dual Gold(III)-Copper(II) Conjugated Phosphorus Dendrimers as Potent Antitumoral and Antimicrobial Agents
Mignani S, El Brahmi N, El Kazzouli S, Laurent R, Ladeira S, Caminade A, et al.
Mol Pharm . 2017 Sep; 14(11):4087-4097. PMID: 28960997
Original metallophosphorus dendrimers (generation 3, 48 terminal groups) have been prepared via the complexation of phosphorus dendrimers bearing imino-pyridino end groups with Au(III) or with both Au(III) and Cu(II). The...
4.
Anticancer copper(II) phosphorus dendrimers are potent proapoptotic Bax activators
Mignani S, El Brahmi N, Eloy L, Poupon J, Nicolas V, Steinmetz A, et al.
Eur J Med Chem . 2017 Mar; 132:142-156. PMID: 28350998
A multivalent phosphorus dendrimer 1G and its corresponding Cu-complex, 1G-Cu have been recently identified as agents retaining high antiproliferative potency. This antiproliferative capacity was preserved in cell lines overexpressing the...
5.
Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment
Jourdan J, Since M, El Kihel L, Lecoutey C, Corvaisier S, Legay R, et al.
ChemMedChem . 2017 Mar; 12(12):913-916. PMID: 28342294
Herein we describe the drug design steps developed to increase the radical scavenging and β-amyloid aggregation inhibitory activities of a previously described series of benzylidenephenylpyrrolizinones. Among the newly synthesized derivatives,...
6.
A novel class of ethacrynic acid derivatives as promising drug-like potent generation of anticancer agents with established mechanism of action
Mignani S, El Brahmi N, El Kazzouli S, Eloy L, Courilleau D, Caron J, et al.
Eur J Med Chem . 2016 Jul; 122:656-673. PMID: 27448922
The well-known diuretic Ethacrynic acid (EA, Edecrin), showing low anti-proliferative activities, was chemically modified at different positions. The new EA derivatives have been tested in vitro in anti-proliferative assays on...
7.
Linking of Antitumor trans NHC-Pt(II) Complexes to G-Quadruplex DNA Ligand for Telomeric Targeting
Betzer J, Nuter F, Chtchigrovsky M, Hamon F, Kellermann G, Ali S, et al.
Bioconjug Chem . 2016 Apr; 27(6):1456-70. PMID: 27115175
G-quadruplex structures (G4) are promising anticancerous targets. A great number of small molecules targeting these structures have already been identified through biophysical methods. In cellulo, some of them are able...
8.
Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment
Jourdan J, Since M, El Kihel L, Lecoutey C, Corvaisier S, Legay R, et al.
Eur J Med Chem . 2016 Apr; 114:365-79. PMID: 27046230
This work describes the synthesis and the biological evaluation of novel benzylidenephenylpyrrolizinones as potential antioxidant, metal chelating or amyloid β (βA) aggregation inhibitors. Some derivatives exhibited interesting results in regard...
9.
Antidiabetic potential of two medicinal plants used in Gabonese folk medicine
Agnaniet H, Jolinom Mbot E, Keita O, Fehrentz J, Ankli A, Gallud A, et al.
BMC Complement Altern Med . 2016 Feb; 16:71. PMID: 26906899
Background: Diabetes mellitus is a metabolic disorder which is rising globally in rich and developing countries. In the African region this rate is the highest, with 20 million diagnosed diabetics....
10.
Boronic species as promising inhibitors of the Staphylococcus aureus NorA efflux pump: study of 6-substituted pyridine-3-boronic acid derivatives
Fontaine F, Hequet A, Voisin-Chiret A, Bouillon A, Lesnard A, Cresteil T, et al.
Eur J Med Chem . 2015 Mar; 95:185-98. PMID: 25817769
In response to the extensive use of antibiotics, bacteria have evolved numerous mechanisms of defense against antimicrobial agents. Among them, extrusion of the antimicrobial agents outside the bacterial cell through...