Theodore C Jessop
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Explore the profile of Theodore C Jessop including associated specialties, affiliations and a list of published articles.
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13
Citations
556
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Recent Articles
1.
Rouse W, Andrews R, Booher N, Wang J, Woodman M, Dow E, et al.
NAR Genom Bioinform
. 2022 Jan;
4(1):lqab127.
PMID: 35047817
In recent years, interest in RNA secondary structure has exploded due to its implications in almost all biological functions and its newly appreciated capacity as a therapeutic agent/target. This surge...
2.
Amigo J, Rama-Garda R, Bello X, Sobrino B, de Blas J, Martin-Ortega M, et al.
SLAS Discov
. 2018 Jan;
23(5):397-404.
PMID: 29361864
Available tools to analyze sequencing data coming from DNA-encoded chemical libraries (DELs) are often limited to in-house methods, which usually rely on strictly looking for the particular DEL structure used....
3.
Castanon J, Roman J, Jessop T, de Blas J, Haro R
SLAS Discov
. 2018 Jan;
23(5):387-396.
PMID: 29361863
DNA-encoded libraries (DELs) have emerged as an efficient and cost-effective drug discovery tool for the exploration and screening of very large chemical space using small-molecule collections of unprecedented size. Herein,...
4.
Hargiss L, Zipp G, Jessop T, Sun X, Keyes P, Rawlins D, et al.
J Chromatogr B Analyt Technol Biomed Life Sci
. 2014 Oct;
971:120-5.
PMID: 25282130
An ultra high-pressure liquid chromatography/mass spectrometry (UHPLC/MS) separation and analysis method has been devised for open access analysis of synthetic reactions used in the production of DNA-encoded chemical libraries. The...
5.
Salojin K, Hamman B, Chang W, Jhaver K, Al-Shami A, Crisostomo J, et al.
PLoS One
. 2014 May;
9(5):e98151.
PMID: 24852423
Mammalian sterile 20-like kinase 1 (Mst1) is a MAPK kinase kinase kinase which is involved in a wide range of cellular responses, including apoptosis, lymphocyte adhesion and trafficking. The contribution...
6.
Bagdanoff J, Donoviel M, Nouraldeen A, Carlsen M, Jessop T, Tarver J, et al.
J Med Chem
. 2010 Nov;
53(24):8650-62.
PMID: 21090716
Sphingosine 1-phosphate lyase (S1PL) has been characterized as a novel target for the treatment of autoimmune disorders using genetic and pharmacological methods. Medicinal chemistry efforts targeting S1PL by direct in...
7.
Jessop T, Tarver J, Carlsen M, Xu A, Healy J, Heim-Riether A, et al.
Bioorg Med Chem Lett
. 2009 Oct;
19(23):6784-7.
PMID: 19836232
A series of deoxycytidine kinase inhibitors was simultaneously optimized for potency and PK properties. A co-crystal structure then allowed merging this series with a high throughput screening hit to afford...
8.
Tarver J, Jessop T, Carlsen M, Augeri D, Fu Q, Healy J, et al.
Bioorg Med Chem Lett
. 2009 Oct;
19(23):6780-3.
PMID: 19836229
A series of potent piperidine-linked cytosine derivatives were prepared as inhibitors of deoxycytidine kinase (dCK). Compound 9h was discovered to be a potent inhibitor of dCK and shows a good...
9.
Bagdanoff J, Donoviel M, Nouraldeen A, Tarver J, Fu Q, Carlsen M, et al.
J Med Chem
. 2009 Jun;
52(13):3941-53.
PMID: 19489538
During nearly a decade of research dedicated to the study of sphingosine signaling pathways, we identified sphingosine-1-phosphate lyase (S1PL) as a drug target for the treatment of autoimmune disorders. S1PL...
10.
Rothbard J, Jessop T, Wender P
Adv Drug Deliv Rev
. 2005 Feb;
57(4):495-504.
PMID: 15722160
A mechanistic hypothesis is presented for how water-soluble guanidinium-rich transporters attached to small cargoes (MW ca. <3000) can migrate across the non-polar lipid membrane of a cell and enter the...