Marianne Carlsen
Overview
Explore the profile of Marianne Carlsen including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
113
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0
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Recent Articles
1.
Shi H, Tice C, Emert-Sedlak L, Chen L, Li W, Carlsen M, et al.
ACS Infect Dis
. 2019 Nov;
6(2):302-312.
PMID: 31775511
The HIV-1 Nef accessory factor is critical to the viral life cycle and promotes immune escape of infected cells via downregulation of cell-surface MHC-I. Previously, we discovered small molecules that...
2.
Bagdanoff J, Donoviel M, Nouraldeen A, Carlsen M, Jessop T, Tarver J, et al.
J Med Chem
. 2010 Nov;
53(24):8650-62.
PMID: 21090716
Sphingosine 1-phosphate lyase (S1PL) has been characterized as a novel target for the treatment of autoimmune disorders using genetic and pharmacological methods. Medicinal chemistry efforts targeting S1PL by direct in...
3.
Jessop T, Tarver J, Carlsen M, Xu A, Healy J, Heim-Riether A, et al.
Bioorg Med Chem Lett
. 2009 Oct;
19(23):6784-7.
PMID: 19836232
A series of deoxycytidine kinase inhibitors was simultaneously optimized for potency and PK properties. A co-crystal structure then allowed merging this series with a high throughput screening hit to afford...
4.
Tarver J, Jessop T, Carlsen M, Augeri D, Fu Q, Healy J, et al.
Bioorg Med Chem Lett
. 2009 Oct;
19(23):6780-3.
PMID: 19836229
A series of potent piperidine-linked cytosine derivatives were prepared as inhibitors of deoxycytidine kinase (dCK). Compound 9h was discovered to be a potent inhibitor of dCK and shows a good...
5.
Bagdanoff J, Donoviel M, Nouraldeen A, Tarver J, Fu Q, Carlsen M, et al.
J Med Chem
. 2009 Jun;
52(13):3941-53.
PMID: 19489538
During nearly a decade of research dedicated to the study of sphingosine signaling pathways, we identified sphingosine-1-phosphate lyase (S1PL) as a drug target for the treatment of autoimmune disorders. S1PL...
6.
Guo J, Watson A, Kempson J, Carlsen M, Barbosa J, Stebbins K, et al.
Bioorg Med Chem Lett
. 2009 Mar;
19(7):1935-8.
PMID: 19272774
A series of pyrimidine based inhibitors of PDE7 are discussed. The synthesis, structure-activity relationships (SAR) and selectivity against several other PDE family members as well as activity in T cells...
7.
Murali Dhar T, Watterson S, Chen P, Shen Z, Gu H, Norris D, et al.
Bioorg Med Chem Lett
. 2003 Feb;
13(3):547-51.
PMID: 12565969
The synthesis and the structure-activity relationships (SAR) of analogues derived from the introduction of basic residues on ring D of quinolone-based inhibitors of IMPDH are described. This led to the...
8.
Watterson S, Carlsen M, Murali Dhar T, Shen Z, Pitts W, Guo J, et al.
Bioorg Med Chem Lett
. 2003 Feb;
13(3):543-6.
PMID: 12565968
A series of novel quinolone-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are described.