Qinghong Fu
Overview
Explore the profile of Qinghong Fu including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
40
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0
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Recent Articles
1.
Qiu X, Deng J, Fu Q, Lou Y, Ye Y, Zhang D
Materials (Basel)
. 2025 Jan;
18(1.
PMID: 39795802
Asphalt pavement, widely utilized in transportation infrastructure due to its favourable properties, faces significant degradation from chloride salt erosion in coastal areas and winter deicing regions. In this study, two...
2.
Dong S, VanGelder K, Shi Z, Yu Y, Wu Z, Ferguson R, et al.
Bioorg Med Chem Lett
. 2017 Apr;
27(11):2559-2566.
PMID: 28431879
SAR in the previously described spirocyclic ROMK inhibitor series was further evolved from lead 4 by modification of the spirocyclic core and identification of novel right-side pharmacophores. In this process,...
3.
Xu J, Lin S, Myers R, Trujillo M, Pachanski M, Malkani S, et al.
Bioorg Med Chem Lett
. 2017 Mar;
27(9):2063-2068.
PMID: 28284809
Systemically acting glucokinase activators (GKA) have been demonstrated in clinical trials to effectively lower blood glucose in patients with type II diabetes. However, mechanism-based hypoglycemia is a major adverse effect...
4.
Xu J, Lin S, Myers R, Addona G, Berger J, Campbell B, et al.
Bioorg Med Chem Lett
. 2017 Mar;
27(9):2069-2073.
PMID: 28284804
Glucokinase (GK, hexokinase IV) is a unique hexokinase that plays a central role in mammalian glucose homeostasis. Glucose phosphorylation by GK in the pancreatic β-cell is the rate-limiting step that...
5.
Jessop T, Tarver J, Carlsen M, Xu A, Healy J, Heim-Riether A, et al.
Bioorg Med Chem Lett
. 2009 Oct;
19(23):6784-7.
PMID: 19836232
A series of deoxycytidine kinase inhibitors was simultaneously optimized for potency and PK properties. A co-crystal structure then allowed merging this series with a high throughput screening hit to afford...
6.
Tarver J, Jessop T, Carlsen M, Augeri D, Fu Q, Healy J, et al.
Bioorg Med Chem Lett
. 2009 Oct;
19(23):6780-3.
PMID: 19836229
A series of potent piperidine-linked cytosine derivatives were prepared as inhibitors of deoxycytidine kinase (dCK). Compound 9h was discovered to be a potent inhibitor of dCK and shows a good...
7.
Bagdanoff J, Donoviel M, Nouraldeen A, Tarver J, Fu Q, Carlsen M, et al.
J Med Chem
. 2009 Jun;
52(13):3941-53.
PMID: 19489538
During nearly a decade of research dedicated to the study of sphingosine signaling pathways, we identified sphingosine-1-phosphate lyase (S1PL) as a drug target for the treatment of autoimmune disorders. S1PL...