Tetsuya Kitamine
Overview
Explore the profile of Tetsuya Kitamine including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
8
Citations
188
Followers
0
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Recent Articles
1.
Yonetomi Y, Sekioka T, Kadode M, Kitamine T, Kamiya A, Inoue A, et al.
Eur J Pharmacol
. 2015 Aug;
765:242-8.
PMID: 26318198
We assessed in this study the anti-asthmatic effects of ONO-6950, a novel cysteinyl leukotriene 1 (CysLT1) and 2 (CysLT2) receptors dual antagonist, in normal and S-hexyl glutathione (S-hexyl GSH)-treated guinea...
2.
Itadani S, Yashiro K, Aratani Y, Sekiguchi T, Kinoshita A, Moriguchi H, et al.
J Med Chem
. 2015 Jul;
58(15):6093-113.
PMID: 26200813
An orally active dual CysLT1 and CysLT2 antagonist possessing a distinctive structure which consists of triple bond and dicarboxylic acid moieties is described. Gemilukast (ONO-6950) was generated via isomerization of...
3.
Nagashima S, Yagyu H, Tozawa R, Tazoe F, Takahashi M, Kitamine T, et al.
J Lipid Res
. 2015 Mar;
56(5):998-1005.
PMID: 25755092
Squalene synthase (SS) catalyzes the biosynthesis of squalene, the first specific intermediate in the cholesterol biosynthetic pathway. To test the feasibility of lowering plasma cholesterol by inhibiting hepatic SS, we...
4.
Yonetomi Y, Sekioka T, Kadode M, Kitamine T, Kamiya A, Matsumura N, et al.
Eur J Pharmacol
. 2015 Feb;
754:98-104.
PMID: 25704617
Cysteinyl leukotrienes act through G-protein-coupled receptors termed cysteinyl leukotriene 1 (CysLT1) and cysteinyl leukotriene 2 (CysLT2) receptors. However, little is known about the pathophysiological role of CysLT2 receptors in asthma....
5.
Okazaki H, Tazoe F, Okazaki S, Isoo N, Tsukamoto K, Sekiya M, et al.
J Lipid Res
. 2006 Jun;
47(9):1950-8.
PMID: 16741291
Squalene synthase (SS) is the first committed enzyme for cholesterol biosynthesis, located at a branch point in the mevalonate pathway. To examine the role of SS in the overall cholesterol...
6.
Ohashi K, Osuga J, Tozawa R, Kitamine T, Yagyu H, Sekiya M, et al.
J Biol Chem
. 2003 Aug;
278(44):42936-41.
PMID: 12920113
The endoplasmic reticulum (ER) enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which converts HMG-CoA to mevalonate, catalyzes the ratelimiting step in cholesterol biosynthesis. Because this mevalonate pathway also produces several non-sterol...
7.
Yoshikawa T, Ide T, Shimano H, Yahagi N, Amemiya-Kudo M, Matsuzaka T, et al.
Mol Endocrinol
. 2003 May;
17(7):1240-54.
PMID: 12730331
Liver X receptors (LXRs) and peroxisome proliferator-activated receptors (PPARs) are members of nuclear receptors that form obligate heterodimers with retinoid X receptors (RXRs). These nuclear receptors play crucial roles in...
8.
Okazaki H, Osuga J, Tsukamoto K, Isoo N, Kitamine T, Tamura Y, et al.
J Biol Chem
. 2002 May;
277(35):31893-9.
PMID: 12036961
Cholesterol ester (CE)-laden foam cells are a hallmark of atherosclerosis. To determine whether stimulation of the hydrolysis of cytosolic CE can be used as a novel therapeutic modality of atherosclerosis,...