Hitoshi Shimano
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Explore the profile of Hitoshi Shimano including associated specialties, affiliations and a list of published articles.
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Articles
308
Citations
8958
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Recent Articles
1.
Yokoo T, Watanabe K, Iida K, Nakachi Y, Suzuki H, Shimano H, et al.
J Biol Chem
. 2025 Jan;
301(2):108202.
PMID: 39826690
Recent success with the use of glucagon-like peptide-1 (GLP-1) receptor analogs and dipeptidyl peptidase-4 inhibitors for the treatment of patients with diabetes has highlighted the role of the intestine as...
2.
Iwasaki H, Yagyu H, Shimano H
J Atheroscler Thromb
. 2025 Jan;
PMID: 39805627
Diabetes mellitus, particularly type 2 diabetes mellitus (T2DM), is a pervasive chronic disease that affects millions of people worldwide. It predisposes individuals to a range of severe microvascular and macrovascular...
3.
Sato N, Goyama S, Chang Y, Miyawaki M, Fujino T, Koide S, et al.
Nat Cardiovasc Res
. 2024 Dec;
3(12):1568-1583.
PMID: 39653824
Certain somatic mutations provide a fitness advantage to hematopoietic stem cells and lead to clonal expansion of mutant blood cells, known as clonal hematopoiesis (CH). Among the most common CH...
4.
Matsuda T, Osaki Y, Sekiya M, Shimano H
BMJ Case Rep
. 2024 Nov;
17(11).
PMID: 39581682
A man in his late 30s with gait difficulty, dysarthria, impaired consciousness and polyuria was diagnosed with left thalamic infarction. Hypercalcaemia (3.52 mmol/L (2.15-2.52)), high intact-parathyroid hormone (i-PTH) levels (88.8 ...
5.
Horikawa C, Takahara M, Katakami N, Takeda Y, Takeuchi M, Fujihara K, et al.
Diabetes Obes Metab
. 2024 Oct;
27(1):394-406.
PMID: 39466701
Aims: Many guidelines recommend increases in potassium intake. However, the relationship of dietary potassium intake with incident cardiovascular disease (CVD) has not been examined in those with type 2 diabetes...
6.
Oxysterol binding protein regulates the resolution of TLR-induced cytokine production in macrophages
Diercks A, Podolskaia I, Murray T, Jahn A, Mai D, Liu D, et al.
Proc Natl Acad Sci U S A
. 2024 Oct;
121(33):e2406492121.
PMID: 39361877
Toll-like receptors (TLRs) on macrophages sense microbial components and trigger the production of numerous cytokines and chemokines that mediate the inflammatory response to infection. Although many of the components required...
7.
Karkoutly S, Takeuchi Y, Mehrazad Saber Z, Ye C, Tao D, Aita Y, et al.
Biochem Biophys Res Commun
. 2024 Aug;
739:150594.
PMID: 39191148
When amino acids are plentiful in the diet, the liver upregulates most enzymes responsible for amino acid degradation. In particular, the activity of urea cycle enzymes increases in response to...
8.
Matsuda T, Osaki Y, Maruo K, Matsuda E, Suzuki Y, Suzuki H, et al.
BMC Nephrol
. 2024 Aug;
25(1):264.
PMID: 39152372
Background: To evaluate the seasonal variability of urinary albumin to creatinine ratio (UACR) and eGFR and these effects on three-year eGFR slope in persons with type 2 diabetes (T2D). Methods:...
9.
Nishiyama T, Ohyama A, Miki H, Asashima H, Kondo Y, Tsuboi H, et al.
Clin Immunol
. 2024 Aug;
266:110337.
PMID: 39111562
Rheumatoid arthritis (RA) is an autoimmune disease characterized by a polyarticular synovitis. In recent years, elderly onset rheumatoid arthritis (EORA) has been increasing. Treg cells in RA have been reported...
10.
Cao Y, Araki M, Nakagawa Y, Deisen L, Lundsgaard A, Kanta J, et al.
Mol Metab
. 2024 Jul;
87:101991.
PMID: 39019116
Objective: Dietary medium-chain fatty acids (MCFAs), characterized by chain lengths of 8-12 carbon atoms, have been proposed to have beneficial effects on glucose and lipid metabolism, yet the underlying mechanisms...