Teppei Shimamura
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Explore the profile of Teppei Shimamura including associated specialties, affiliations and a list of published articles.
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106
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5136
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Recent Articles
1.
Sato T, Abe K, Koseki J, Seto M, Yokoyama J, Akashi T, et al.
Sci Rep
. 2024 Nov;
14(1):26322.
PMID: 39487149
Establishing a sustainable life-support system for space exploration is a formidable challenge due to the vast distances, high costs, and environmental differences from Earth. Building upon the lessons from the...
2.
Mizukoshi C, Kojima Y, Nomura S, Hayashi S, Abe K, Shimamura T
Genome Biol
. 2024 Sep;
25(1):229.
PMID: 39237934
Messenger RNA splicing and degradation are critical for gene expression regulation, the abnormality of which leads to diseases. Previous methods for estimating kinetic rates have limitations, assuming uniform rates across...
3.
Majima K, Kojima Y, Minoura K, Abe K, Hirose H, Shimamura T
Bioinformatics
. 2024 Aug;
40(10).
PMID: 39172488
Motivation: Single-cell RNA sequencing (scRNA-seq) enables comprehensive characterization of the cell state. However, its destructive nature prohibits measuring gene expression changes during dynamic processes such as embryogenesis or cell state...
4.
Hashimoto M, Kojima Y, Sakamoto T, Ozato Y, Nakano Y, Abe T, et al.
EBioMedicine
. 2024 Apr;
103:105102.
PMID: 38614865
Background: Cell-cell interaction factors that facilitate the progression of adenoma to sporadic colorectal cancer (CRC) remain unclear, thereby hindering patient survival. Methods: We performed spatial transcriptomics on five early CRC...
5.
Kojima Y, Mii S, Hayashi S, Hirose H, Ishikawa M, Akiyama M, et al.
Cell Syst
. 2024 Feb;
15(2):180-192.e7.
PMID: 38387441
Analyzing colocalization of single cells with heterogeneous molecular phenotypes is essential for understanding cell-cell interactions, and cellular responses to external stimuli and their biological functions in diseases and tissues. However,...
6.
Fujino S, Miyoshi N, Ito A, Hayashi R, Yasui M, Matsuda C, et al.
Commun Biol
. 2023 Nov;
6(1):1191.
PMID: 37996567
Circulating tumor cells (CTCs) play an important role in metastasis and recurrence. However, which cells comprise the complex tumor lineages in recurrence and are key in metastasis are unknown in...
7.
Li M, Nishimura T, Takeuchi Y, Hongu T, Wang Y, Shiokawa D, et al.
J Clin Invest
. 2023 Nov;
133(22).
PMID: 37966117
The heterogeneity of cancer stem cells (CSCs) within tumors presents a challenge in therapeutic targeting. To decipher the cellular plasticity that fuels phenotypic heterogeneity, we undertook single-cell transcriptomics analysis in...
8.
Kato M, Maeda K, Nakahara R, Hirose H, Kondo A, Aki S, et al.
PNAS Nexus
. 2023 Oct;
2(10):pgad306.
PMID: 37822765
An acidic tumor microenvironment plays a critical role in tumor progression. However, understanding of metabolic reprogramming of tumors in response to acidic extracellular pH has remained elusive. Using comprehensive metabolomic...
9.
Nakahara R, Aki S, Sugaya M, Hirose H, Kato M, Maeda K, et al.
EMBO J
. 2023 Oct;
42(22):e114032.
PMID: 37781951
Bone marrow-derived cells (BMDCs) infiltrate hypoxic tumors at a pre-angiogenic state and differentiate into mature macrophages, thereby inducing pro-tumorigenic immunity. A critical factor regulating this differentiation is activation of SREBP2-a...
10.
Abe K, Shimamura T
Brief Bioinform
. 2023 Jul;
24(5).
PMID: 37478378
Factor analysis, ranging from principal component analysis to nonnegative matrix factorization, represents a foremost approach in analyzing multi-dimensional data to extract valuable patterns, and is increasingly being applied in the...