Tarsis F Brust
Overview
Explore the profile of Tarsis F Brust including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
19
Citations
589
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Volf A, Brust T, Kobylski R, Czekner K, Stahl E, Cameron M, et al.
bioRxiv
. 2025 Mar;
PMID: 40027836
Abstract Figure:
2.
Brust T, Ostrom R, Watts V
Front Pharmacol
. 2022 Dec;
13:1098240.
PMID: 36569292
No abstract available.
3.
Giacoletti G, Price T, Hoelz L, Shremo Msdi A, Cossin S, Vazquez-Falto K, et al.
Front Pharmacol
. 2022 Jul;
13:935588.
PMID: 35899113
Among the ten different adenylyl cyclase isoforms, studies with knockout animals indicate that inhibition of AC1 can relieve pain and reduce behaviors linked to opioid dependence. We previously identified ST034307...
4.
Ostrom K, LaVigne J, Brust T, Seifert R, Dessauer C, Watts V, et al.
Physiol Rev
. 2021 Oct;
102(2):815-857.
PMID: 34698552
Adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second messenger cAMP. Mammals possess nine isoforms of transmembrane ACs, dubbed AC1-9, that serve as major effector enzymes of...
5.
Brust T
Handb Exp Pharmacol
. 2020 Nov;
271:115-135.
PMID: 33140224
The kappa opioid receptor (KOR) is a G protein-coupled receptor (GPCR) that can signal through multiple signaling pathways. KOR agonists are known to relieve pain and itch, as well as...
6.
Price T, Brust T
Pharmacol Res
. 2019 Mar;
143:106-112.
PMID: 30904753
Adenylyl cyclases (ACs) are enzymes that catalyze the production of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). Humans express nine isoforms of membranous ACs and a soluble AC. Studies...
7.
Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists
Tosh D, Ciancetta A, Mannes P, Warnick E, Janowsky A, Eshleman A, et al.
ACS Omega
. 2018 Nov;
3(10):12658-12678.
PMID: 30411015
While screening off-target effects of rigid ()-methanocarba-adenosine 5'-methylamides as A adenosine receptor (AR) agonists, we discovered μM binding hits at the δ-opioid receptor (DOR) and translocator protein (TSPO). In an...
8.
Hirasawa S, Cho M, Brust T, Roach J, Bohn L, Shenvi R
Bioorg Med Chem Lett
. 2018 Feb;
28(16):2770-2772.
PMID: 29426768
Salvinorin A (SalA) is a potent and selective agonist of the kappa-opioid receptor (KOR), but its instability has frustrated medicinal chemistry efforts. Treatment of SalA with weak bases like DBU...
9.
Brust T, Alongkronrusmee D, Soto-Velasquez M, Baldwin T, Ye Z, Dai M, et al.
Sci Signal
. 2017 Feb;
10(467).
PMID: 28223412
Adenylyl cyclase 1 (AC1) belongs to a group of adenylyl cyclases (ACs) that are stimulated by calcium in a calmodulin-dependent manner. Studies with AC1 knockout mice suggest that inhibitors of...
10.
Brust T, Morgenweck J, Kim S, Rose J, Locke J, Schmid C, et al.
Sci Signal
. 2016 Dec;
9(456):ra117.
PMID: 27899527
Agonists targeting the kappa opioid receptor (KOR) have been promising therapeutic candidates because of their efficacy for treating intractable itch and relieving pain. Unlike typical opioid narcotics, KOR agonists do...