Tamas Bartfai
Overview
Explore the profile of Tamas Bartfai including associated specialties, affiliations and a list of published articles.
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108
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4414
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Recent Articles
21.
Osborn O, Oh D, McNelis J, Sanchez-Alavez M, Talukdar S, Lu M, et al.
J Clin Invest
. 2012 Jun;
122(7):2444-53.
PMID: 22653059
Obesity-induced inflammation is a key component of systemic insulin resistance, which is a hallmark of type 2 diabetes. A major driver of this inflammation/insulin resistance syndrome is the accumulation of...
22.
Dubins J, Sanchez-Alavez M, Zhukov V, Sanchez-Gonzalez A, Moroncini G, Carvajal-Gonzalez S, et al.
Metabolism
. 2012 May;
61(10):1486-93.
PMID: 22560055
The G protein-coupled receptor 83 (GPR83) was recently demonstrated in warm sensitive neurons (WSN) of the hypothalamic preoptic area (POA) that participate in temperature homeostasis. Thus, we investigated whether GPR83...
23.
Bartfai T, Buckley P, Eberwine J
Trends Pharmacol Sci
. 2011 Oct;
33(1):9-16.
PMID: 22032985
Drug discovery in neuro- and psychopharmacology is lagging, and the most commonly mentioned cause is the scarcity of drug targets. Using NextGen 'sequencing based single-cell transcriptomics' (SBSCT), several hundred different...
24.
Sagi V, Liu T, Lu X, Bartfai T, Roberts E
Bioorg Med Chem Lett
. 2011 Oct;
21(23):7210-5.
PMID: 22018787
GalR1 and GalR2 represent unique pharmacological targets for treatment of seizures and epilepsy. A novel series of 2,4,6-triaminopyrimidine derivatives were synthesized and found to have sub-micromolar affinity for GalR2. Optimization...
25.
Klein I, Sanchez-Alavez M, Tabarean I, Schaefer J, Holmberg K, Klaus J, et al.
Brain Res
. 2011 Oct;
1423:1-9.
PMID: 22000082
Adiponectin can act in the brain to increase energy expenditure and reduce body weight by mechanisms not entirely understood. We found that adiponectin type 1 and type 2 receptors (AdipoR1...
26.
Vezzani A, Bartfai T, Bianchi M, Rossetti C, French J
Epilepsia
. 2011 Oct;
52 Suppl 8:67-9.
PMID: 21967368
Experimental and clinical findings have shown in the past decade that specific proinflammatory mediators and their cognate receptors are upregulated in epileptic brain tissue. In particular, the IL-1 receptor (R)/Toll-like...
27.
Bajo M, Madamba S, Lu X, Sharkey L, Bartfai T, Siggins G
Addict Biol
. 2011 Sep;
17(4):694-705.
PMID: 21955024
The neuropeptide galanin and its three receptor subtypes (GalR1-3) are expressed in the central amygdala (CeA), a brain region involved in stress- and anxiety-related behaviors, as well as alcohol dependence....
28.
Vezzani A, Maroso M, Balosso S, Sanchez M, Bartfai T
Brain Behav Immun
. 2011 Apr;
25(7):1281-9.
PMID: 21473909
Increasing evidence supports the involvement of immune and inflammatory processes in the etiopathogenesis of seizures. In particular, activation of innate immune mechanisms and the subsequent inflammatory responses, that are induced...
29.
Bartfai T, Lees G
ScientificWorldJournal
. 2011 Feb;
11:454-7.
PMID: 21336460
Within days of each other, Pfizer, Merck, and GlaxoSmithKline announced that they will focus on a few therapeutic areas only and abandon others entirely. Pfizer alone will close well over...
30.
Sanchez-Alavez M, Osborn O, Tabarean I, Holmberg K, Eberwine J, Kahn C, et al.
J Biol Chem
. 2011 Feb;
286(17):14983-90.
PMID: 21330367
The objective is to investigate the role of insulin-like growth factor 1 (IGF-1) in the regulation of core body temperature. Sequencing cDNA libraries from individual warm-sensitive neurons from the preoptic...