Tamara Delaine
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Explore the profile of Tamara Delaine including associated specialties, affiliations and a list of published articles.
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19
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540
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Recent Articles
11.
Diehl C, Engstrom O, Delaine T, Hakansson M, Genheden S, Modig K, et al.
J Am Chem Soc
. 2010 Sep;
132(41):14577-89.
PMID: 20873837
Rational drug design is predicated on knowledge of the three-dimensional structure of the protein-ligand complex and the thermodynamics of ligand binding. Despite the fundamental importance of both enthalpy and entropy...
12.
Delaine T, Bernardes-Genisson V, Quemard A, Constant P, Meunier B, Bernadou J
Eur J Med Chem
. 2010 Aug;
45(10):4554-61.
PMID: 20696503
Isoniazid-NAD truncated adducts embedding a lipophilic fragment were designed, synthesized and evaluated as inhibitors of the enoyl-acyl carrier protein (ACP) reductase (InhA) of Mycobacterium tuberculosis and as antimycobacterial agents. These...
13.
Rives A, Le Calve B, Delaine T, Legentil L, Kiss R, Delfourne E
Eur J Med Chem
. 2009 Nov;
45(1):343-51.
PMID: 19897281
Two series of analogues of the marine pyrroloiminoquinone alkaloids tsitsikammamine have been synthesized on the basis of a Michael addition between 2'-amino-1-(4-methoxyphenyl)-ethanol and two indolediones. All the compounds were evaluated...
14.
Lin C, Whang E, Donner D, Jiang X, Price B, Carothers A, et al.
Mol Cancer Res
. 2009 Oct;
7(10):1655-62.
PMID: 19825987
Although most patients with papillary thyroid cancer (PTC) have favorable outcomes, some have advanced PTC that is refractory to external beam radiation and systemic chemotherapy. Galectin-3 (Gal-3) is a beta-galactoside-binding...
15.
Oberg C, Noresson A, Delaine T, Larumbe A, Tejler J, Wachenfeldt H, et al.
Carbohydr Res
. 2009 Jun;
344(11):1282-4.
PMID: 19505681
Three efficient routes to 3-azido-3-deoxy-beta-D-galactopyranosides were developed relying on a double inversion protocol at C3. Two of the routes were demonstrated to work with both O- and S-glycosides. In all...
16.
Delaine T, Cumpstey I, Ingrassia L, Mercier M, Okechukwu P, Leffler H, et al.
J Med Chem
. 2008 Dec;
51(24):8109-14.
PMID: 19053747
Aromatic 3,3'-diesters of thiodigalactoside were synthesized in a rapid three-step sequence from commercially available thiodigalactoside and evaluated as inhibitors of cancer- and immunity-related galectins. For each of galectins-1, -3, -7,...
17.
Stigliani J, Arnaud P, Delaine T, Bernardes-Genisson V, Meunier B, Bernadou J
J Mol Graph Model
. 2008 Oct;
27(4):536-45.
PMID: 18955002
The front-line antituberculosis drug isoniazid (INH) inhibits InhA, the NADH-dependent fatty acid biosynthesis enoyl ACP-reductase from Mycobacterium tuberculosis, via formation of covalent adducts with NAD (INH-NAD adducts). While ring tautomers...
18.
Meloni G, Sonois V, Delaine T, Guilloreau L, Gillet A, Teissie J, et al.
Nat Chem Biol
. 2008 May;
4(6):366-72.
PMID: 18454142
Aberrant interactions of copper and zinc ions with the amyloid-beta peptide (Abeta) potentiate Alzheimer's disease (AD) by participating in the aggregation process of Abeta and in the generation of reactive...
19.
Delaine T, Bernardes-Genisson V, Meunier B, Bernadou J
J Org Chem
. 2007 Jan;
72(2):675-8.
PMID: 17221997
The first syntheses of the 1-hydroxy-1-(pyridin-4-yl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one heterocycle and the 3-aminocarbonyl-4-isonicotinoyl-1,4-dihydropyridine framework present in the isoniazid-NAD(P) adducts are described.