Hakon Leffler
Overview
Explore the profile of Hakon Leffler including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
151
Citations
4843
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
MacDonald E, Forrester A, Valades-Cruz C, Madsen T, Hetmanski J, Dransart E, et al.
Nat Cell Biol
. 2025 Feb;
27(3):545.
PMID: 40000851
No abstract available.
2.
Puric E, Hassan M, Sjovall F, Tomasic T, Pevec M, Lah J, et al.
Commun Chem
. 2025 Feb;
8(1):59.
PMID: 39994474
Galectin-8 is a tandem-repeat galectin consisting of two distinct carbohydrate recognition domains and is a potential drug target. We have developed a library of galectin-8N inhibitors that exhibit high nanomolar...
3.
MacDonald E, Forrester A, Valades-Cruz C, Madsen T, Hetmanski J, Dransart E, et al.
Nat Cell Biol
. 2025 Feb;
27(3):449-463.
PMID: 39984654
Glycolipid-lectin-driven endocytosis controls the formation of clathrin-independent carriers and the internalization of various cargos such as β1 integrin. Whether this process is regulated in a dynamic manner remained unexplored. Here...
4.
Karlsson V, Stal E, Stoopendahl E, Ivarsson A, Leffler H, Lycke M, et al.
Front Immunol
. 2025 Jan;
15:1506236.
PMID: 39759523
Introduction: Ovarian cancer is a lethal disease with low survival rates for women diagnosed in advanced stages. Current cancer immunotherapies are not efficient in ovarian cancer, and there is therefore...
5.
Peterson K, Nilsson U, Gravelle L, Holyer I, Jansson K, Kahl-Knutson B, et al.
J Med Chem
. 2024 Dec;
67(24):21905-21915.
PMID: 39668131
The interest in galectin-3 as a drug target in the cancer and fibrosis space has grown during the past few years with several new classes of compounds being developed. The...
6.
Mahanti M, Gummesson S, Sundin A, Leffler H, Zetterberg F, Nilsson U
Bioorg Med Chem
. 2024 Nov;
116:117989.
PMID: 39549501
Four directional and positional variants of sulfonamide-derivatized galactopyranosides were synthesized and evaluated against human galectin-1, -3, -4C (C-terminal), -7, -8N (N-terminal), -8C (C-terminal), -9N (N-terminal), and -9C (C-terminal), which revealed...
7.
MacKinnon A, Humphries D, Herman K, Roper J, Holyer I, Mabbitt J, et al.
Eur J Pharmacol
. 2024 Nov;
985:177077.
PMID: 39528104
Background And Purpose: Galectin-3 (Gal-3) is a pro-fibrotic β-galactoside binding lectin highly expressed in fibrotic liver and implicated in hepatic fibrosis. GB1107 is a novel orally active Gal-3 small molecule...
8.
Shafaq-Zadah M, Dransart E, Mani S, Sampaio J, Bouidghaghen L, Nilsson U, et al.
Biomolecules
. 2024 Sep;
14(9).
PMID: 39334935
Essentially all plasma membrane proteins are glycosylated, and their activity is regulated by tuning their cell surface dynamics. This is achieved by glycan-binding proteins of the galectin family that either...
9.
Comeglio P, Guarnieri G, Filippi S, Cellai I, Acciai G, Holyer I, et al.
Front Pharmacol
. 2024 Aug;
15:1430109.
PMID: 39144627
Introduction: Galectin-3 is a pro-fibrotic β-galactoside binding lectin highly expressed in fibrotic liver and implicated in hepatic fibrosis. Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small...
10.
van Klaveren S, Hassan M, Hakansson M, Johnsson R, Larsson J, Jakopin Z, et al.
ACS Med Chem Lett
. 2024 Aug;
15(8):1319-1324.
PMID: 39140038
Galectin-8 contains two different carbohydrate recognition domains (CRDs). Selective inhibitors for at least one CRD are desirable for galectin-8 biology studies and potentially for pharmacological purposes. Structure-guided design led to...