Takeshi Harayama
Overview
Explore the profile of Takeshi Harayama including associated specialties, affiliations and a list of published articles.
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34
Citations
1642
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Recent Articles
1.
Gollowitzer A, Pein H, Rao Z, Waltl L, Bereuter L, Loeser K, et al.
Nat Commun
. 2025 Feb;
16(1):1774.
PMID: 40000627
Cell death programs such as apoptosis and ferroptosis are associated with aberrant redox homeostasis linked to lipid metabolism and membrane function. Evidence for cross-talk between these programs is emerging. Here,...
2.
Chen X, Don A, Fedorova M, Harayama T, Krahmer N, Nagata S, et al.
Nat Cell Biol
. 2025 Feb;
27(2):169-174.
PMID: 39910286
No abstract available.
3.
Takeda H, Matsuzawa Y, Takeuchi M, Takahashi M, Nishida K, Harayama T, et al.
Nat Commun
. 2024 Nov;
15(1):9903.
PMID: 39609386
Lipidomics and metabolomics communities comprise various informatics tools; however, software programs handling multimodal mass spectrometry (MS) data with structural annotations guided by the Lipidomics Standards Initiative are limited. Here, we...
4.
Harayama T
Biochimie
. 2023 Sep;
215:34-41.
PMID: 37769936
Cellular lipids have an enormous diversity in their chemical structures, which affect the physicochemical properties of lipids and membranes, as well as their regulatory roles on protein functions. Here, I...
5.
Harayama T, Antonny B
Cold Spring Harb Perspect Biol
. 2023 Jun;
15(7).
PMID: 37277191
The number of double bonds in the acyl chains of membrane lipids varies tremendously at all scales of life, from the organism level to the subcellular level, where differences in...
6.
Jose G, Harayama T
EMBO J
. 2022 Aug;
41(18):e112163.
PMID: 35924974
Two recent complementary studies show that, after phospholipase C cleavage, the characteristic acyl chain composition of phosphoinositide-derived diacylglycerol funnels them back into the PI cycle.
7.
Hamano F, Matoba K, Hashidate-Yoshida T, Suzuki T, Miura K, Hishikawa D, et al.
FASEB J
. 2021 May;
35(6):e21501.
PMID: 33956375
Platelet-activating factor (PAF) is a potent proinflammatory phospholipid mediator that elicits various cellular functions and promotes several pathological events, including anaphylaxis and neuropathic pain. PAF is biosynthesized by two types...
8.
Hannich J, Loizides-Mangold U, Sinturel F, Harayama T, Vandereycken B, Saini C, et al.
Acta Physiol (Oxf)
. 2020 Dec;
232(1):e13610.
PMID: 33351229
Aim: The worldwide increase in obesity and type 2 diabetes (T2D) represents a major health challenge. Chronically altered lipids induced by obesity further promote the development of T2D, and the...
9.
Harayama T, Shimizu T
J Lipid Res
. 2020 Jun;
61(8):1150-1160.
PMID: 32487545
PUFAs, such as AA and DHA, are recognized as important biomolecules, but understanding their precise roles and modes of action remains challenging. PUFAs are precursors for a plethora of signaling...
10.
Harayama T
Curr Biol
. 2020 Feb;
30(3):R122-R124.
PMID: 32017882
A new study compares two sister species of fission yeast that use very different fatty acids to make membrane lipids and reveals an adaptation in transmembrane helix lengths that maintains...