Takashi Isobe
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Explore the profile of Takashi Isobe including associated specialties, affiliations and a list of published articles.
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Articles
71
Citations
446
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Recent Articles
1.
Hanioka N, Isobe T, Saito K, Nagaoka K, Mori Y, Jinno H, et al.
Comp Biochem Physiol C Toxicol Pharmacol
. 2024 Jun;
283:109962.
PMID: 38889874
Tizoxanide (TZX) is an active metabolite of nitazoxanide (NTZ) originally developed as an antiparasitic agent, and is predominantly metabolized into TZX glucuronide. In the present study, TZX glucuronidation by the...
2.
Sugi T, Inubushi T, Ohno T, Onishi Y, Isobe T, Shigematsu T, et al.
Sci Rep
. 2024 Jan;
14(1):758.
PMID: 38191647
Cough is known as a protective reflex to keep the airway free from harmful substances. Although brain activity during cough was previously examined mainly by functional magnetic resonance imaging (fMRI)...
3.
Hanioka N, Isobe T, Saito K, Nagaoka K, Mori Y, Jinno H, et al.
Arch Toxicol
. 2024 Jan;
98(3):837-848.
PMID: 38182911
Tetrabromobisphenol A (TBBPA) and tetrachlorobisphenol A (TCBPA), bisphenol A (BPA) analogs, are endocrine-disrupting chemicals predominantly metabolized into glucuronides by UDP-glucuronosyltransferase (UGT) enzymes in humans and rats. In the present study,...
4.
Ote K, Hashimoto F, Onishi Y, Isobe T, Ouchi Y
IEEE Trans Med Imaging
. 2023 Apr;
42(6):1822-1834.
PMID: 37022039
List-mode positron emission tomography (PET) image reconstruction is an important tool for PET scanners with many lines-of-response and additional information such as time-of-flight and depth-of-interaction. Deep learning is one possible...
5.
Isobe T, Ohkawara S, Mori Y, Jinno H, Tanaka-Kagawa T, Hanioka N
Chem Biol Interact
. 2023 Jan;
372:110353.
PMID: 36657734
Phthalates are widely used plasticizers that are primarily and rapidly metabolized to monoester phthalates in mammals. In the present study, the hydrolysis of dibutyl phthalate (DBP) and di(2-ethylhexyl) phthalate (DEHP)...
6.
Mori Y, Tanaka-Kagawa T, Tahara M, Kawakami T, Aoki A, Okamoto Y, et al.
J Toxicol Sci
. 2023 Jan;
48(1):37-45.
PMID: 36599426
Transient Receptor Potential Ankyrin 1 (TRPA1), which is expressed in the airways, has causative and exacerbating roles in respiratory diseases. TRPA1 is known as a target of sick building syndrome-related...
7.
Li Y, Watanabe M, Isobe T, Ote K, Tokui A, Omura T, et al.
Phys Med Biol
. 2022 Dec;
68(1).
PMID: 36560889
. The aim of this study is to evaluate the performance characteristics of a brain positron emission tomography (PET) scanner composed of four-layer independent read-out time-of-flight depth-of-interaction (TOF-DOI) detectors capable...
8.
Mori Y, Aoki A, Okamoto Y, Isobe T, Ohkawara S, Hanioka N, et al.
Biol Pharm Bull
. 2022 Oct;
45(12):1839-1846.
PMID: 36223942
Phthalic acid (PA) diesters are widely used in consumer products, as plasticizers, and are ubiquitous environmental pollutants. There is a growing concern about their adjuvant effect on allergic diseases. Although...
9.
Mori Y, Aoki A, Okamoto Y, Isobe T, Ohkawara S, Hanioka N, et al.
Biol Pharm Bull
. 2022 Jul;
45(8):1185-1190.
PMID: 35908900
Bitter taste receptors (TAS2Rs) are expressed by oral cavity cells in mammals and classically function as sensors for bitter compounds. There are 25 functional isoforms of human TAS2Rs, with individual...
10.
Hanioka N, Tanaka-Kagawa T, Mori Y, Ikushiro S, Jinno H, Ohkawara S, et al.
Biol Pharm Bull
. 2022 Jul;
45(8):1116-1123.
PMID: 35908893
Flavones, which are distributed in a variety of plants and foods in nature, possess significant biological activities, including antitumor and anti-inflammatory effects, and are metabolized into glucuronides by uridine 5'-diphosphate...