Nobumitsu Hanioka
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Explore the profile of Nobumitsu Hanioka including associated specialties, affiliations and a list of published articles.
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80
Citations
420
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Recent Articles
1.
Hanioka N, Isobe T, Saito K, Nagaoka K, Mori Y, Jinno H, et al.
Comp Biochem Physiol C Toxicol Pharmacol
. 2024 Jun;
283:109962.
PMID: 38889874
Tizoxanide (TZX) is an active metabolite of nitazoxanide (NTZ) originally developed as an antiparasitic agent, and is predominantly metabolized into TZX glucuronide. In the present study, TZX glucuronidation by the...
2.
Hanioka N, Isobe T, Saito K, Nagaoka K, Mori Y, Jinno H, et al.
Arch Toxicol
. 2024 Jan;
98(3):837-848.
PMID: 38182911
Tetrabromobisphenol A (TBBPA) and tetrachlorobisphenol A (TCBPA), bisphenol A (BPA) analogs, are endocrine-disrupting chemicals predominantly metabolized into glucuronides by UDP-glucuronosyltransferase (UGT) enzymes in humans and rats. In the present study,...
3.
Isobe T, Ohkawara S, Mori Y, Jinno H, Tanaka-Kagawa T, Hanioka N
Chem Biol Interact
. 2023 Jan;
372:110353.
PMID: 36657734
Phthalates are widely used plasticizers that are primarily and rapidly metabolized to monoester phthalates in mammals. In the present study, the hydrolysis of dibutyl phthalate (DBP) and di(2-ethylhexyl) phthalate (DEHP)...
4.
Mori Y, Tanaka-Kagawa T, Tahara M, Kawakami T, Aoki A, Okamoto Y, et al.
J Toxicol Sci
. 2023 Jan;
48(1):37-45.
PMID: 36599426
Transient Receptor Potential Ankyrin 1 (TRPA1), which is expressed in the airways, has causative and exacerbating roles in respiratory diseases. TRPA1 is known as a target of sick building syndrome-related...
5.
Mori Y, Aoki A, Okamoto Y, Isobe T, Ohkawara S, Hanioka N, et al.
Biol Pharm Bull
. 2022 Oct;
45(12):1839-1846.
PMID: 36223942
Phthalic acid (PA) diesters are widely used in consumer products, as plasticizers, and are ubiquitous environmental pollutants. There is a growing concern about their adjuvant effect on allergic diseases. Although...
6.
Mori Y, Aoki A, Okamoto Y, Isobe T, Ohkawara S, Hanioka N, et al.
Biol Pharm Bull
. 2022 Jul;
45(8):1185-1190.
PMID: 35908900
Bitter taste receptors (TAS2Rs) are expressed by oral cavity cells in mammals and classically function as sensors for bitter compounds. There are 25 functional isoforms of human TAS2Rs, with individual...
7.
Hanioka N, Tanaka-Kagawa T, Mori Y, Ikushiro S, Jinno H, Ohkawara S, et al.
Biol Pharm Bull
. 2022 Jul;
45(8):1116-1123.
PMID: 35908893
Flavones, which are distributed in a variety of plants and foods in nature, possess significant biological activities, including antitumor and anti-inflammatory effects, and are metabolized into glucuronides by uridine 5'-diphosphate...
8.
Kitaguchi T, Mizota T, Ito M, Ohno K, Kobayashi K, Ogawa I, et al.
Drug Metab Dispos
. 2021 Oct;
50(1):17-23.
PMID: 34670778
Pharmacokinetic prediction after oral ingestion is important for quantitative risk assessment of food-derived compounds. To evaluate the utility of human intestinal absorption prediction, we compared the membrane permeability and metabolic...
9.
Hanioka N, Saito K, Isobe T, Ohkawara S, Jinno H, Tanaka-Kagawa T
Biopharm Drug Dispos
. 2021 Mar;
42(5):218-225.
PMID: 33754379
Favipiravir is an antiviral agent effective against several RNA viruses that is converted into an inactive oxidative metabolite (M1), mainly by aldehyde oxidase, in humans. In the present study, the...
10.
Hanioka N, Isobe T, Tanaka-Kagawa T, Jinno H, Ohkawara S
Drug Chem Toxicol
. 2020 Nov;
45(4):1565-1569.
PMID: 33187449
Bisphenol A (BPA) is an endocrine-disrupting chemical, and is predominantly metabolized into glucuronide in mammals. The present study was conducted in order to examine the hepatic and intestinal glucuronidation of...