Takanori Hashizume
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Explore the profile of Takanori Hashizume including associated specialties, affiliations and a list of published articles.
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20
Citations
376
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Recent Articles
11.
Usui T, Mise M, Hashizume T, Yabuki M, Komuro S
Drug Metab Dispos
. 2009 Sep;
37(12):2383-92.
PMID: 19720731
Prediction of idiosyncratic drug-induced liver injury (DILI) is difficult, and the underlying mechanisms are not fully understood. However, many drugs causing DILI are considered to form reactive metabolites and covalently...
12.
Mizuno K, Katoh M, Okumura H, Nakagawa N, Negishi T, Hashizume T, et al.
Drug Metab Dispos
. 2008 Nov;
37(2):345-51.
PMID: 19005028
Cytochrome P450 3A4 is the predominant isoform in liver, and it metabolizes more than 50% of the clinical drugs commonly used. However, CYP3A4 is also responsible for metabolic activation of...
13.
Mise M, Hashizume T, Komuro S
Drug Metab Dispos
. 2008 Jun;
36(9):1903-8.
PMID: 18573860
Beagle dogs are commonly used for toxicological and pharmacological studies of drug candidates in the pharmaceutical industry. Recently, we reported a CYP1A2-deficient dog with a nonsense mutation (C1117T). In this...
14.
Hashizume T, Xu Y, Mohutsky M, Alberts J, Hadden C, Kalhorn T, et al.
Biochem Pharmacol
. 2008 Jan;
75(5):1240-50.
PMID: 18177842
The biological effects of 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) are terminated primarily by P450-dependent hydroxylation reactions. However, the hormone is also conjugated in the liver and a metabolite, presumably a glucuronide, undergoes...
15.
Imaoka S, Hashizume T, Funae Y
Drug Metab Pharmacokinet
. 2006 Jan;
20(6):478-84.
PMID: 16415532
Metabolites of arachidonic acid produced by P450 are interesting substances with prominent physiological functions. To elucidate the physiological function of P450, it is necessary to identify a specific P450 in...
16.
Xu Y, Hashizume T, Shuhart M, Davis C, Nelson W, Sakaki T, et al.
Mol Pharmacol
. 2005 Oct;
69(1):56-65.
PMID: 16207822
The decline in bone mineral density that occurs after long-term treatment with some antiepileptic drugs is thought to be mediated by increased vitamin D(3) metabolism. In this study, we show...
17.
Iwasaki M, Yoshimura Y, Asahi S, Saito K, Sakai S, Morita S, et al.
Drug Metab Pharmacokinet
. 2005 Feb;
19(6):444-52.
PMID: 15681899
As a part of the studies conducted by the Pharma SNPs Consortium (PSC), the enzyme activities of CYP1A2, CYP2A6 and CYP2B6 variants with altered amino acids as a result of...
18.
Mise M, Hashizume T, Matsumoto S, Terauchi Y, Fujii T
Pharmacogenetics
. 2004 Nov;
14(11):769-73.
PMID: 15564884
Objectives: Recently, we reported that AC-3933, a novel cognitive enhancer, is polymorphically hydroxylated in beagle dogs and that dogs could be phenotyped as extensive metabolizers (EM) or poor metabolizers (PM)....
19.
Mise M, Yadera S, Matsuda M, Hashizume T, Matsumoto S, Terauchi Y, et al.
Drug Metab Dispos
. 2004 Jan;
32(2):240-5.
PMID: 14744947
5-(3-methoxyphenyl)-3-(5-methyl-1,2,4-oxadiazol-3-yl)-2-oxo-1,2-dihydro-1,6-naphthyridine (AC-3933) is a novel cognitive enhancer with central benzodiazepine receptor partial inverse agonistic activity. AC-3933 is predominantly metabolized to hydroxylated metabolite [SX-5745; 3-(5-hydroxymethyl-1,2,4-oxadiazol-3-yl)-5-(3-methoxyphenyl)-2-oxo-1,2-dihydro-1,6-naphthyridine] in dog. Initially, we found that...
20.
Hashizume T, Imaoka S, Mise M, Terauchi Y, Fujii T, Miyazaki H, et al.
J Pharmacol Exp Ther
. 2001 Dec;
300(1):298-304.
PMID: 11752129
The purpose of the study was to elucidate human intestinal cytochrome P450 isoform(s) involved in the metabolism of an antihistamine, ebastine, having two major pathways of hydroxylation and N-dealkylation. The...