Tadatoshi Sato
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Explore the profile of Tadatoshi Sato including associated specialties, affiliations and a list of published articles.
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45
Citations
790
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Recent Articles
1.
Papaioannou G, Sato T, Houghton C, Kotsalidis P, Strauss K, Dean T, et al.
bioRxiv
. 2024 Jul;
PMID: 38979143
Osteocytes are the primary mechano-sensitive cell type in bone. Mechanical loading is sensed across the dendritic projections of osteocytes leading to transient reductions in focal adhesion kinase (FAK) activity. Knowledge...
2.
Sato T, Chaugule S, Greenblatt M, Gao G, Shim J
Hum Gene Ther
. 2024 Apr;
35(9-10):329-341.
PMID: 38661537
The development of bone-targeting drug delivery systems holds immense promise for improving the treatment of skeletal diseases. By precisely delivering therapeutic agents to the affected areas of bone, these strategies...
3.
Yang Y, Sato T, Chaugule S, Ma H, Xie J, Gao G, et al.
Mol Ther Nucleic Acids
. 2024 Jan;
35(1):102111.
PMID: 38261950
Osteogenesis imperfecta (OI) is a genetic disorder characterized by bone fragility, low bone mass, fractures, and extraskeletal manifestations. Since OI is commonly caused by single-nucleotide mutation(s) in the or genes...
4.
Park Y, Sato T, Lee J
Nat Commun
. 2023 Dec;
14(1):8092.
PMID: 38062034
Osteoclasts are the primary target for osteoporosis drug development. Recent animal studies revealed the crucial roles of osteoblasts in regulating osteoclastogenesis and the longer lifespans of osteoclasts than previously thought...
5.
Stavre Z, Kim J, Yang Y, Nundel K, Chaugule S, Sato T, et al.
Proc Natl Acad Sci U S A
. 2023 May;
120(19):e2218019120.
PMID: 37141171
Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to systemic and articular bone loss by activating bone resorption and suppressing bone formation. Despite current therapeutic agents, inflammation-induced bone...
6.
Yoon S, Meyer M, Arevalo C, Tekguc M, Zhang C, Wang J, et al.
J Clin Invest
. 2023 Mar;
133(9).
PMID: 36862513
The renal actions of parathyroid hormone (PTH) promote 1,25-vitamin D generation; however, the signaling mechanisms that control PTH-dependent vitamin D activation remain unknown. Here, we demonstrated that salt-inducible kinases (SIKs)...
7.
Sato T, Castro Andrade C, Yoon S, Zhao Y, Greenlee W, Weber P, et al.
Proc Natl Acad Sci U S A
. 2022 Dec;
119(50):e2214396119.
PMID: 36472957
Osteoporosis is a major public health problem. Currently, there are no orally available therapies that increase bone formation. Intermittent parathyroid hormone (PTH) stimulates bone formation through a signal transduction pathway...
8.
Mazur C, Castro Andrade C, Tokavanich N, Sato T, Bruce M, Brooks D, et al.
iScience
. 2022 Sep;
25(9):105019.
PMID: 36105586
Glucocorticoid excess suppresses osteocyte remodeling of surrounding bone minerals, causes apoptosis of osteoblasts and osteocytes, and disrupts bone remodeling, eventually, leading to glucocorticoid-induced osteoporosis and bone fragility. Preventing apoptosis and...
9.
Fan Y, Cui C, Rosen C, Sato T, Xu R, Li P, et al.
Signal Transduct Target Ther
. 2022 May;
7(1):155.
PMID: 35538062
Maxillofacial bone defects are commonly seen in clinical practice. A clearer understanding of the regulatory network directing maxillofacial bone formation will promote the development of novel therapeutic approaches for bone...
10.
Tang C, Castro Andrade C, OMeara M, Yoon S, Sato T, Brooks D, et al.
Elife
. 2021 Jun;
10.
PMID: 34160349
Bone formation and resorption are typically coupled, such that the efficacy of anabolic osteoporosis treatments may be limited by bone destruction. The multi-kinase inhibitor YKL-05-099 potently inhibits salt inducible kinases...